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Prognostic impact of MUC1 and potential regulatory miR-145 and miR-21 expression in salivary mucoepidermoid carcinoma
BackgroundSalivary gland mucoepidermoid carcinoma (MEC) poses a considerable risk of locoregional and distant metastasis after conventional...
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The relevance of the non-invasive biomarkers lncRNA GAS5/miR-21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy
BackgroundTo investigate the diagnostic value of serum lncRNA growth arrest-specific transcript 5 (lncRNA GAS5) and microRNA-21 (miR-21) in patients...
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Systematic review of overlap** microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis
BackgroundPulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and...
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MicroRNA biomarkers and their use in evaluating the prognosis of lung cancer
ObjectiveWe aim to use the microRNA (miRNA, micro-ribonucleic acid) data of lung cancer tissues to establish a miRNA biomarker database for lung...
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MicroRNA and renal fibrosis in autosomal dominant polycystic kidney disease: a longitudinal study
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disorder that may progress to kidney failure, accounting for...
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AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner
Argonaute proteins, which consist of AGO1, AGO2, AGO3 and AGO4, are key players in microRNA-mediated gene silencing. So far, few non-microRNA related...
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Interrelation of MicroRNAs and Transposons in Aging and Carcinogenesis
AbstractThe dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by the...
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Expression profile of microRNAs may be promising in diagnosis of proliferative diabetic retinopathy: an Egyptian study
PurposeDiabetic retinopathy (DR) is still a leading cause of blindness. The role of miRNAs in diabetic retinopathy still needs more research. We...
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Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of develo** diabetes and in drug-naïve T2D
BackgroundImpaired glucose tolerance (IGT) is a risk factor for the development of diabetes and related complications that ensue. Early...
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Epigenome-wide DNA methylation in obsessive-compulsive disorder
In adult patients with obsessive-compulsive disorder (OCD), altered DNA methylation has been discerned in several candidate genes, while DNA...
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microRNA-21 and hypertension
Hypertension, a multifactorial disease, is a major risk factor for the development of stroke, coronary artery disease, heart failure, and chronic...
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A secondary analysis of indices of hepatic and beta cell function following 12 weeks of carbohydrate and energy restriction vs. free-living control in adults with type 2 diabetes
BackgroundSubstantial weight loss in people living with type 2 diabetes (T2D) can reduce the need for glucose-lowering medications while concurrently...
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Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Recovery from opioid use disorder (OUD) and maintenance of abstinence from opioid use is hampered by perseverant drug cravings that may persist for...
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The RNA-binding protein quaking is upregulated in nitrofen-induced congenital diaphragmatic hernia lungs at the end of gestation
BackgroundThe RNA-binding protein Quaking (QKI) increases during epithelial-to-mesenchymal transition and its expression is controlled by...
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Differential expression of microRNAs targeting genes associated with the development of high-grade gliomas
BackgroundHighly malignant high-grade gliomas are tumors of the central nervous system (CNS). They are solid tumors arising from transformed cells of...
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The effects of aerobic exercise on blood plasma microRNA level in healthy adults: a systematic review and meta-analysis
BackgroundExercise training was found to trigger various phenotypic changes related to preventing numerous diseases. Additionally, it also influences...
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Mechanism of the switch from NO to H2O2 in endothelium-dependent vasodilation in diabetes
Coronary microvascular dysfunction is prevalent among people with diabetes and is correlated with cardiac mortality. Compromised...
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Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability
BackgroundAntioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide...
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microRNA signatures associated with fetal growth restriction: a systematic review
Placental-origin microRNA (miRNA) profiles can be useful toward early diagnosis and management of fetal growth restriction (FGR) and associated...
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Dysregulated microRNA expression in rheumatoid arthritis families—a comparison between rheumatoid arthritis patients, their first-degree relatives, and healthy controls
ObjectiveRecent studies have demonstrated an altered expression of certain microRNAs in patients with rheumatoid arthritis (RA) as well as their...
