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Mitochondrial metabolism: a predictive biomarker of radiotherapy efficacy and toxicity
IntroductionRadiotherapy is a mainstay of cancer treatment. Clinical studies revealed a heterogenous response to radiotherapy, from a complete...
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Efficacy and toxicity of infradiaphragmal radiotherapy fields in lymphoma patients: a single-centre experience
PurposeData on efficacy and toxicity of infradiaphragmal radiotherapy fields in lymphoma patients are scarce. We therefore performed this...
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Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases
Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2...
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Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study
PurposeThe optimal dose and range of radiotherapy for central nervous system (CNS) germinoma have not yet been established. This study aimed to...
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Comparative analysis of treatment decision-making in patients with localized prostate and cervical cancer: what influences receiving surgery or radiotherapy?
PurposeThis study focused on identifying the factors influencing the decision-making process in patients with localized prostate and cervical cancer...
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Pattern of practice of re-irradiation for ipsilateral breast tumor recurrence in Italy: a survey by the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
PurposeThe Re-irradiation and the Breast Cancer Working Groups of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) conducted a...
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Possible mechanisms and simulation modeling of FLASH radiotherapy
FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It delivers radiation doses at an ultra-high dose rate...
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Chemoradiotherapy versus radiotherapy in high risk salivary gland cancer
ObjectiveThe aim of this study was to investigate the potential survival benefits associated with chemoradiotherapy (CRT) as opposed to radiotherapy...
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Excellent long-term pain response and local control following postoperative radiotherapy in patients with multiple myeloma
PurposeMultiple myeloma is associated with osteolytic bone lesions, often requiring surgery of the spine and postoperative radiotherapy (RT)....
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HYPofractionated Adjuvant RadioTherapy in 1 versus 2 weeks in high-risk patients with breast cancer (HYPART): a non-inferiority, open-label, phase III randomised trial
BackgroundBreast cancer is the most common cancer in women. Radiotherapy is an important part of breast cancer treatment after surgery. Breast cancer...
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The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
Approximately 60–80% of cancer patients treated with abdominopelvic radiotherapy suffer post-radiotherapy toxicities including radiation enteropathy...
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Deep-learning-based radiomics of intratumoral and peritumoral MRI images to predict the pathological features of adjuvant radiotherapy in early-stage cervical squamous cell carcinoma
BackgroundSurgery combined with radiotherapy substantially escalates the likelihood of encountering complications in early-stage cervical squamous...
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Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy
Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is...
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Prediction of recurrence-related factors for patients with early-stage cervical cancer following radical hysterectomy and adjuvant radiotherapy
ObjectiveTo analyze recurrent factors in patients with clinical early-stage cervical cancer (ESCC) following hysterectomy and adjuvant radiotherapy.
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Artificial intelligence applied to image-guided radiation therapy (IGRT): a systematic review by the Young Group of the Italian Association of Radiotherapy and Clinical Oncology (yAIRO)
IntroductionThe advent of image-guided radiation therapy (IGRT) has recently changed the workflow of radiation treatments by ensuring highly...
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Effect of radiotherapy on the DNA cargo and cellular uptake mechanisms of extracellular vesicles
In the past decades, plenty of evidence has gathered pointing to the role of extracellular vesicles (EVs) secreted by irradiated cells in the...
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Neutron dose from a 6-MV X-ray beam in radiotherapy
Although a 6-MV X-ray beam is employed clinically as a non-neutron-producing beam, no studies have reported how few neutrons are produced from a 6-MV...
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Radiotherapy in Extramedullary Plasmacytoma of the Tongue with Nodal Involvement: A Case Report with One-Year Follow-Up
Tongue extramedullary plasmacytoma (EMP) with regional lymph node metastases is a very rare pathology. Despite being a rare entity, extramedullary...
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Secondary Budd-Chiari syndrome occurred after adjuvant radiotherapy for perihilar cholangiocarcinoma: a case report
BackgroundBudd–Chiari syndrome (BCS) is a rare vascular disorder of the liver, and acute and secondary BCS is even rarer.
Case presentation ...
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Case report: radiation-induced lumbosacral plexopathy – a very late complication of radiotherapy for cervical cancer
BackgroundLumbosacral plexopathy caused by radiotherapy is a rare but severe consequence of cancer treatment. This condition often leads to varying...
