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Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy
The standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without...
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Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy
Endometriosis is a benign, common, but controversial disease due to its enigmatic etiopathogenesis and biological behavior. Recent studies suggest...
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Ultrasound-guided transvaginal biopsies of pelvic lesions: diagnostic yield, safety profile, and technical considerations over a 20-year experience
PurposeTo evaluate diagnostic yield, safety profile, and specific technical considerations of transvaginal ultrasound (TVUS) guided biopsy/aspiration.
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Spontaneous Tumor Lysis Syndrome in a Case of Hepatocellular Carcinoma with Sarcomatoid Differentiation
Sarcomatoid hepatocellular carcinoma is a rare histologic variant of primary liver cancer comprising of malignant spindle cells and typical...
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Prostein expression in human tumors: a tissue microarray study on 19,202 tumors from 152 different Tumor entities
BackgroundProstein (P501S), also termed solute carrier family 45 member 3 (SLC45A3) is an androgen regulated protein which is preferentially...
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Molecular and histopathology directed therapy for advanced bladder cancer
Bladder cancer is a heterogeneous group of tumours with at least 40 histological subgroups. Patients with localized disease can be cured with...
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Prognostic factors of patients with recurrent uterine malignancies undergoing secondary cytoreductive surgery
BackgroundSeveral studies have demonstrated that secondary cytoreductive surgery (SCS) for patients with recurrent uterine malignancies may improve...
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FIGO 2023 endometrial staging: a leap of faith into the new “prognostic based’ rather than “anatomical based” staging—too fast too furious??
BackgroundIn 2023 FIGO revised the endometrial cancer staging system after 13 years. There is a lacuna of data regarding the performance and...
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A comparison of [18F]AlF- and 68Ga-labeled dual targeting heterodimer FAPI-RGD in malignant tumor: preclinical evaluation and pilot clinical PET/CT imaging
AbstractDue to the heterogeneity of tumors, strategies to improve the effectiveness of dual-targeting tracers in tumor diagnostics have been...
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The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review
PurposeSelinexor is a novel XPO1 inhibitor which inhibits the export of tumor suppressor proteins and oncoprotein mRNAs, leading to cell-cycle arrest...
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SEOM-GEICO clinical guidelines on endometrial cancer (2021)
Endometrial cancer (EC) is the second most common gynecological malignancy worldwide, the first in developed countries [Sung et al. in CA Cancer J...
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Targeted Therapies in the Treatment of Uterine Serous Carcinoma
Despite the dismal prognosis of uterine serous carcinoma (USC), recent advances in molecular classification and targeted treatments have demonstrated...
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Reclassifying tumour cell cycle activity in terms of its tissue of origin
Genomic alterations resulting in loss of control over the cell cycle is a fundamental hallmark of human malignancies. Whilst pan-cancer studies have...
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Extrauterine Endometrial Stromal Sarcoma: A Case Report
Extrauterine endometrial stromal sarcomas are rare malignancies, with 181 cases reported so far. The basic predisposing factor is endometriosis, and...
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An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
BackgroundTo explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
MethodsBased on TCGA and GTEx databases, we used TIMER2.0...
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Primary immature teratoma in the liver with growing teratoma syndrome and gliomatosis peritonei: a rare case report
BackgroundPrimary liver immature teratoma is extremely rare and only 4 cases have been reported, let alone with growing teratoma syndrome (GTS)...
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FABP1 expression in human tumors: a tissue microarray study on 17,071 tumors
Fatty acid–binding proteins (FABPs) play a pivotal role in the metabolism of fatty acids and are expressed in a tissue-specific manner. FABP1 is most...
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SIU–ICUD consultation on bladder cancer: treatment of muscle-invasive bladder cancer
PurposeTo provide a comprehensive overview and update of the Joint Société Internationale d’Urologie–International Consultation on Urological...
