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Insights and implications of sexual dimorphism in osteoporosis
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk...
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Antibacterial Alternatives to a Dying Antibiotic Pipeline
Purpose of reviewThis study summarized the current problems and potential solutions related to the rise of multidrug-resistant bacteria, the lack of...
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Depletion of NK6 Homeobox 3 (NKX6.3) causes gastric carcinogenesis through copy number alterations by inducing impairment of DNA replication and repair regulation
Genomic stability maintenance requires correct DNA replication, chromosome segregation, and DNA repair, while defects of these processes result in...
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Other Causes of Chronic Diarrhea in Children
Chronic diarrhea is still an important cause of morbidity and mortality in children. There are several causes of chronic diarrhea which may be due to...
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Bioinformatics in urology — molecular characterization of pathophysiology and response to treatment
The application of bioinformatics has revolutionized the practice of medicine in the past 20 years. From early studies that uncovered subtypes of...
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Huntington disease-like 2: insight into neurodegeneration from an African disease
Huntington disease (HD)-like 2 (HDL2) is a rare genetic disease caused by an expanded trinucleotide repeat in the JPH3 gene (encoding junctophilin 3)...
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Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1...
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Identification of four insertion sites for foreign genes in a pseudorabies virus vector
BackgroundPseudorabies virus (PRV) is a preferred vector for recombinant vaccine construction. Previously, we generated a TK&gE-deleted PRV (PRV Δ TK&gE−AH02...
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MAP3K4 kinase action and dual role in cancer
It is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the...
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Enzootic epidemiology of Brucella in livestock in central Gansu Province after the National Brucellosis Prevention and Control Plan
Brucellosis remains one of the most common zoonoses spread worldwide, inducing enormous economic losses to the livestock industry and posing serious...
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Intratumoural microbiota: a new frontier in cancer development and therapy
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies...
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Genomic imbalance in euploid pregnancy loss
PurposeThis study aims to investigate genomic imbalance in euploid products of conceptions (POCs) detected by chromosomal microarray analysis (CMA)...
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New insights in pediatrics in 2021: choices in allergy and immunology, critical care, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, neurology, nutrition, palliative care, respiratory tract illnesses and telemedicine
In this review, we report the developments across pediatric subspecialties that have been published in the Italian Journal of Pediatrics in 2021. We...
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Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation
BackgroundEmerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying...
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A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
BackgroundPreterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal...
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Recent Advances in Mesothelioma
Purpose of ReviewPleural mesothelioma (PM) is a rare but fatal cancer of the pleural surface. Most patients have a poor prognosis, despite treatment...
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Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons
Striatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as...
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A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers
In clinical practice, differentiating Bipolar Disorder (BD) from unipolar depression is a challenge due to the depressive symptoms, which are the...
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5G mobile networks and health—a state-of-the-science review of the research into low-level RF fields above 6 GHz
The increased use of radiofrequency (RF) fields above 6 GHz, particularly for the 5 G mobile phone network, has given rise to public concern about...
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Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements
BackgroundNRG1 fusion is a promising therapeutic target for various tumors but its prevalence is extremely low, and there are no standardized testing...
