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Urine-derived stem cell therapy for diabetes mellitus and its complications: progress and challenges
Diabetes mellitus (DM) is a chronic and relentlessly progressive metabolic disease characterized by a relative or absolute deficiency of insulin in...
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MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis
ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of...
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Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a dismal prognosis. The average life expectancy of untreated patients with IPF is...
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Variation in information needs of patients with interstitial lung disease and their family caregivers according to long-term oxygen therapy: a descriptive study
BackgroundThe information needs of patients and their families regarding interstitial lung disease (ILD) have yet to be studied in detail, and few...
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Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis
BackgroundLiver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including...
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The effect of nintedanib on lung functions and survival in idiopathic pulmonary fibrosis: real-life analysis of the Czech EMPIRE registry
IntroductionThe antifibrotic drug nintedanib is used for the treatment of idiopathic pulmonary fibrosis (IPF). We analysed the effect of nintedanib...
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Humoral response among patients with interstitial lung disease vaccinated with the BNT162b2 SARS-Cov-2 vaccine: a prospective cohort study
BackgroundPatients with interstitial lung disease (ILD) are at high risk of severe COVID-19 infection. Additionally, their anti-inflammatory and...
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Stem cell therapy for hepatocellular carcinoma and end-stage liver disease
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD)....
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Combination Therapy of Endoscopic Gastric Remodeling with GLP-1RA for the Treatment of MASLD
PurposeThe mainstay of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) is weight loss. Endoscopic gastric remodeling...
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Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction
Purpose of the ReviewCancer therapy-related cardiac dysfunction (CTRCD) has been identified as a threat to overall and cancer-related survival....
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Possible value of antifibrotic drugs in patients with progressive fibrosing non-IPF interstitial lung diseases
BackgroundFibrosing, non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases (fILDs) are a heterogeneous group of diseases...
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Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patients
PurposeSynovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following...
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Treatment patterns, healthcare resource utilization, and costs among patients with idiopathic pulmonary fibrosis treated with antifibrotic medications in US-based commercial and Medicare Supplemental claims databases: a retrospective cohort study
BackgroundPirfenidone and nintedanib are antifibrotic therapies which slow disease progression in idiopathic pulmonary fibrosis (IPF), an...
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Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Before becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an...
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Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
BackgroundChronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective...
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Efficacy and safety of intravenous immunoglobulin therapy in systemic sclerosis: a systematic review
Background and objectiveSystemic sclerosis (SSc) is a highly heterogeneous disease whose treatment is based mainly on immunosuppressants,...
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Comorbidity burden and survival in patients with idiopathic pulmonary fibrosis: the EMPIRE registry study
BackgroundPatients with idiopathic pulmonary fibrosis (IPF) frequently have multiple comorbidities, which may influence survival but go...
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Assessing the impact of continuous positive airway pressure therapy on clinical outcomes in interstitial lung disease patients with coexisting obstructive sleep apnea: a systematic review
PurposeInterstitial lung disease (ILD) often coexists with obstructive sleep apnea (OSA), contributing to increased morbidity and mortality. However,...
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Association between anti-PL7 antibodies and increased fibrotic component in patients with antisynthetase syndrome and interstitial lung disease: a cross-sectional study
ObjectiveTo evaluate whether anti-PL7 and anti-PL12 autoantibodies are associated with a greater extent of the fibrotic component of ILD in ASSD...
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Epidemiology, healthcare utilization, and related costs among patients with IPF: results from a German claims database analysis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive form of fibrosing interstitial pneumonia with poor survival. This study provides...
