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A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation
Forty patients with multiple myeloma scheduled to receive melphalan 200 mg/m 2 followed by autologous stem cell transplantation were randomly assigned...
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Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies
BackgroundDiarrhoea and constipation are common toxicities of chemotherapy, and both are poorly understood. They are manifestations of alimentary...
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High-dose melphalan (200 mg/m2) supported by autologous stem cell transplantation is safe and effective in elderly (⩾65 years) myeloma patients: comparison with younger patients treated on the same protocol
Limited information is available on the feasibility and efficacy of autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients >65...
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Alimentary mucositis: putting the guidelines into practice
BackgroundThe Mucositis Study Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology...
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Develo** evidence-based guidelines for management of alimentary mucositis: process and pitfalls
IntroductionIt is important yet difficult to maintain currency in clinical oncology practice. The emergence of new diagnostic technologies and new...
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Reduced-intensity conditioning for acute myeloid leukemia: is this strategy correct
Allogeneic stem cell transplantation for acute myeloid leukemia (AML) using reduced-intensity conditioning (RIC) is based on the strategy of...
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Graft-versus-tumor effects on murine mammary carcinoma in a model of nonmyeloablative haploidentical stem cell transplantation
Despite a slight decrease in mortality over the last decade, breast cancer still remains a leading cause of cancer-related death in women. Although...
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Role of cytokines in the treatment of acute leukemias: a review
Myeloid growth factors, such as granulocyte colony-stimulating factor and granulocyte–macrophage colony-stimulating factor, have been used to...
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Cutaneous Reactions to Chemotherapy and their Management
International data from 2002 report 10.9 million new cases of cancer and 6.7 million cancer deaths. Chemotherapy is an essential component in the...
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A prospective, double-blind phase II study evaluating the safety and efficacy of a topical histamine gel for the prophylaxis of oral mucositis in patients post hematopoietic stem cell transplantation
The aim of this study was to evaluate the safety, tolerability and efficacy of a topical gel containing histamine dihydrochloride (HDC) versus a...
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Autologous stem cell transplantation in elderly (>60 years) patients with non-Hodgkin's lymphoma: a nation-wide analysis
Limited experience is available on the feasibility and efficacy of autologous stem cell transplantation (ASCT) in elderly patients with non-Hodgkin's...
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Opioids in pain management of blood-related malignancies
Opioids are basic analgesics used in the treatment of moderate to severe pain in patients affected by blood-related malignancies. They should be...
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Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage
Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis)...
