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Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level and are important for coordinating nervous system development and...
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MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis
PurposeThis study compared miRNA expression patterns in primary squamous cell lung carcinoma specimens with those of matched normal lung tissue in...
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Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
BackgroundGonadal differentiation in the mammalian fetus involves a complex dose-dependent genetic network. Initiation and progression of fetal...
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Onconase mediated NFKβ downregulation in malignant pleural mesothelioma
Treatment of malignant pleural mesothelioma (MPM) with Ranpirnase (Onconase) results in disruption of protein translation and cell apoptosis. We...
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Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium
There are known differences in the properties of hair cells along the tonotopic axis of the avian auditory epithelium, the basilar papilla (BP). To...
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Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter
MicroRNA (miRNA) expression was assessed in human cerebral cortical gray matter (GM) and white matter (WM) in order to provide the first insights...
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miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer
Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of...
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MicroRNAs: Novel Diagnostic and Therapeutic Tools for Pancreatic Ductal Adenocarcinoma?
Pancreatic ductal adenocarcinoma (PDAC) is known for its very poor overall prognosis, making tools for early diagnosis and new therapeutic modalities...
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MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell
MicroRNAs (miRNAs) are an abundant class of short noncoding RNAs that can posttranscriptionally regulate gene expression in animals. They are also...
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Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
MicroRNAs (miRNAs) control the expression of protein-coding genes in normal hematopoietic cells and, consequently, aberrant expression may contribute...
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Assessment of the MicroRNA System in Salt-Sensitive Hypertension
Most animal microRNAs are imperfectly complementary to their mRNA targets and inhibit protein synthesis through an unknown mechanism. MicroRNAs have...