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System Xc−: a key regulatory target of ferroptosis in cancer
Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by excessive lipid peroxide accumulation. This novel cell death...
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Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drug classes with wide therapeutic applications over the...
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Emerging agents that target signaling pathways in cancer stem cells
Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer; however, there are still no drugs targeting CSCs in...
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A highly annotated database of genes associated with platinum resistance in cancer
Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed to 10-20% of all cancer patients. Unfortunately,...
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Ferroptosis, a new form of cell death: opportunities and challenges in cancer
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases...
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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular switches in regulating key cellular functions. Their dysregulation is a...
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Radiation-induced tumor immune microenvironments and potential targets for combination therapy
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various...
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Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy
Aims/hypothesisDiabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent...
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Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive...
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Role of ferroptosis in hepatocellular carcinoma
PurposeHepatocellular carcinoma (HCC) is a complicated disease with low survival rate due to frequent recurrence and the lack of efficient therapies....
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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism...
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Targeting apoptosis in cancer therapy
For over three decades, a mainstay and goal of clinical oncology has been the development of therapies promoting the effective elimination of cancer...
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The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death
The maintenance of genome stability is essential for the cell as the integrity of genomic information guaranties reproduction of a whole organism....
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The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of...
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The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In...
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Autophagy and Ferroptosis—What Is the Connection?
Purpose of ReviewAutophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase....
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Admixture, Genetics and Complex Diseases in Latin Americans and US Hispanics
Purpose of the ReviewWe review population and epidemiological genetics studies in Latin Americans and US Hispanics/Latinos, who are product of...
