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Strong Correlation between Results of Fluorescent In Situ Hybridization and Immunohistochemistry for the Assessment of the ERBB2 (HER-2/neu) Gene Status in Breast Carcinoma
ERBB2 (HER-2/ neu ) amplification and/or overexpression are associated with poor prognosis in node-positive breast carcinoma. Its prognostic value in...
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Pathologie und Molekularbiologie bösartiger pulmonaler Tumoren
Therapy and prognosis of lung cancer depend crucially on tumor size, tumor stage, and the histomorphological tumor type at the time of primary...
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Development of a cancer vaccine: peptides, proteins, and DNA
Genetic changes leading to protooncogene activation qualitatively and/or quantitatively alter their gene products and are exclusively or largely...
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Prognostic significance of biologic markers in node-negative breast cancer patients: a prospective study
It is generally thought that future advances in the treatment and cure of breast cancer patients will be made possible through a deeper understanding...
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Association of human papillomavirus infection with carcinoma of the cervix uteri and its precursor lesions: theoretical and practical implications
Human papillomaviruses (HPVs) are the major aetiological agents of cervical carcinoma. In this review, epidemiological and molecular data are...
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Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies
Poly(ethylene glycol) (PEG) modification of substances with antitumor activity was shown to enhance penetration into growing solid tumors and extend...
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Bone marrow “micrometastases” of epithelial tumors: detection and clinical relevance
The detection and elimination of “micrometastases” or, more precisely, isolated disseminated tumor cells or minimal residual disease is one of the...
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Ras activation in human breast cancer
Genetic ras mutations are infrequent in breast cancer but Ras may be pathologically activated in breast cancer by overexpression of growth factor...
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Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
The interaction between the
erbB tyrosine kinase receptors and their ligands plays an important role in tumor growth via the regulation of autocrine...
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The growth and metastasis of human, HER-2/neu-overexpressing tumor cell lines in male SCID mice
HER-2/neu is overexpressed on a variety of human adenocarcinomas and overexpression has been associated with a poor prognosis. For this reason, HER-2...
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Prognostic Significance of Immunohistochemically Localized Biomarkers in Stage II and Stage III Breast Cancer: A Multivariate Analysis
Background: The aim was to investigate the expression of a panel of biomarkers such as prolactin (PRL), p53, Bcl-2, c-erb B2, Ki-67, CD44, and factor...
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Expression of erbB-3 protein in colorectal adenocarcinoma: correlation with poor survival
Background/aims: The family of erbB receptors includes four transmembrane glycoproteins with tyrosine kinase activity. These receptors are widely... -
Prognostic significance of c-erb B-2 protein status using an enzyme immunoassay in breast cancer
Background. The prognostic significance of c-erb B-2 in breast cancer remains controversial. The aim of this study was to determine the practical... -
Docetaxel
AbstractDocetaxel, a semisynthetic member of the taxoid class of antineoplastic agents, is effective in the treatment of patients with advanced...
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Growth Factors in Gliomas Revisited
¶ Overexpression or untimely expression of wild-type or mutated protein growth factors and their receptors is associated with the biology of...
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The ErbB Receptors as Targets for Breast Cancer Therapy
Breast carcinomas express high levels of ErbBreceptors and their ligands, and their overexpressionhas been associated with a more aggressive...
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Expression of C-erbB-2/HER-2 in patients with metastatic breast cancer undergoing high-dose chemotherapy and autologous blood stem cell support
C-erbB-2/HER-2 (designated HER-2) is overexpressed in both primary and metastatic breast cancer and predicts poor prognosis. We investigated the...