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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite...
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Multi-site desmoplastic small round cell tumors are genetically related and immune-cold
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue sarcoma that is characterized by the EWSR1-WT1 fusion protein....
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Molecular targets and therapeutics in chemoresistance of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a specific subtype of breast cancer (BC), which shows immunohistochemically negative expression of hormone...
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Metabolism and immunity in breast cancer
Breast cancer is one of the most common malignancies that seriously threaten women’s health. In the process of the malignant transformation of breast...
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Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung adenocarcinoma, patients with lung squamous cell carcinoma...
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The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent
BackgroundThe EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC...
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New Directions in Vulvar Cancer Pathology
Purpose of ReviewThe aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and...
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High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer
Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for human epidermal growth factor receptor 2 (HER2)...
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Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition
The receptor tyrosine kinase Ret, a key gain-of-function mutated oncoprotein in thyroid carcinomas, has recently been implicated in other cancer...
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Targeted Agents in Cervical Cancer: Beyond Bevacizumab
Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients...
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Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer
PurposeA correlation between breast cancer and thyroid disorders has been described in previous studies. Degraded thyroid hormones are referred to as...
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Advances in ovarian cancer therapy
Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence...
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Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
The epidermal growth factor receptor (EGFR) is a transmembrane receptor with tyrosine kinase activity involved in regulation of cellular...
