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Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study
Bipolar disorder co-occurs with alcohol use disorder at a rate 3–5 times higher than the general population. We recently reported that individuals...
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Bed Nucleus of the Stria Terminalis (BNST) neurons containing the serotonin 5HT2c receptor modulate operant alcohol self-administration behavior in mice
The serotonin 5HT 2c receptor has been widely implicated in the pathophysiology of alcohol use disorder (AUD), particularly alcohol seeking and the...
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N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice
The endocannabinoid system (ECS) plays a key modulatory role during synaptic plasticity and homeostatic processes in the brain and has an important...
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Activation of GABAB receptors in central amygdala attenuates activity of PKCδ + neurons and suppresses punishment-resistant alcohol self-administration in rats
Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We recently used alcohol self-administration that is resistant...
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Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied...
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High-intensity sweet taste as a predictor of subjective alcohol responses to the ascending limb of an intravenous alcohol prime: an fMRI study
High-intensity sweet-liking has been linked to alcohol use disorder (AUD) risk. However, the neural underpinning of this association is poorly...
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Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder
Alcohol use disorders can be driven by negative reinforcement. Alterations of the microtubule cytoskeleton have been associated with mood regulation...
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Parent-Youth Relationships and Youth Alcohol Use: The Moderating Role of Parental Alcohol Use
Previous studies have shown that strong parent-youth relationships serve as a protective factor inhibiting early alcohol use onset among youth, while...
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Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research
There is inherent tension between methodologies developed to address basic research questions in model species and those intended for preclinical to...
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Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of...
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Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement
Most patients with alcohol-associated liver disease (ALD) engage in heavy drinking defined as 4 or more drinks per day (56 g) or 8 (112 g) or more...
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Treatment of alcohol use disorder in patients with alcohol-associated liver disease: Innovative approaches and a call to action
Alcohol-associated liver disease is currently the leading cause of liver transplantation and liver deaths both in Europe and the United States....
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Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders
A hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that...
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Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid. Few treatments exist to reduce comorbid PTSD/AUD....
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Support after return to alcohol use: a mixed-methods study on how abstinence motivation and app use change after return to alcohol use in an app-based aftercare intervention for individuals with alcohol use disorder
BackgroundAs the return to alcohol use in individuals with alcohol use disorder (AUD) is common during treatment and recovery, it is important that...
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Vancouver’s Alcohol Knowledge Exchange: lessons learned from creating a peer-involved alcohol harm reduction strategy in Vancouver’s Downtown Eastside
Despite high rates of harm attributable to alcohol use itself and the associated marginalization of illicit drinkers in Vancouver’s Downtown Eastside...
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Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse....
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Alcohol, the overlooked drug: clinical pharmacist perspectives on addressing alcohol in primary care
BackgroundAttempts to routinely embed brief interventions in health systems have long been challenging, with healthcare professionals concerned about...
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Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
PurposeCrime-related spiking of alcoholic drinks with prescription drugs is quite common and has been happening for centuries. This study, therefore,...
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The role of alcohol and patterns of alcohol-related deaths in Republic of North Macedonia within the period 2007–2020
Excessive alcohol consumption is one of the most important factors in a substantial number of violent deaths. The aim of our study was to investigate...
