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Develo** a community-responsive research model in the healthcare system: a mixed-method study
BackgroundResponsiveness to the population’s non-clinical needs encompasses various dimensions, including responsive research and an educational...
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An updated analysis of safety climate and downstream outcomes in two convenience samples of U.S. fire departments (FOCUS 1.0 and 2.0 survey waves)
BackgroundThe Fire service Organizational Culture of Safety (FOCUS) survey is an assessment tool comprised of psychometrically validated metrics of...
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Single-year change in views of democracy and society and support for political violence in the USA: findings from a 2023 nationally representative survey
BackgroundA 2022 survey in the USA found concerningly high prevalences of support for and personal willingness to engage in political violence, of...
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Fidelity, pragmatism and the “grey line” in between—exploring the delivery of a pragmatic physical activity randomised controlled trial—a secondary analysis
BackgroundIntervention fidelity in health services research has been poor with a reported lack of understanding about what constitutes pragmatic...
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The quality of reporting in case reports of permanent neonatal diabetes mellitus: a cross-sectional study
BackgroundAlthough randomized trials and systematic reviews provide the best evidence to guide medical practice, many permanent neonatal diabetes...
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Stacked probability plots of the extended illness-death model using constant transition hazards – an easy to use shiny app
BackgroundExtended illness-death models (a specific class of multistate models) are a useful tool to analyse situations like hospital-acquired...
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Weighted metrics are required when evaluating the performance of prediction models in nested case–control studies
BackgroundNested case–control (NCC) designs are efficient for develo** and validating prediction models that use expensive or difficult-to-obtain...
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Identification of patients’ smoking status using an explainable AI approach: a Danish electronic health records case study
BackgroundSmoking is a critical risk factor responsible for over eight million annual deaths worldwide. It is essential to obtain information on...
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Multimorbidity prevalence and health outcome prediction: assessing the impact of lookback periods, disease count, and definition criteria in health administrative data at the population-based level
BackgroundHealth administrative databases play a crucial role in population-level multimorbidity surveillance. Determining the appropriate...
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A joinpoint analysis examining trends in firearm injuries at six us trauma centers from 2016 to 2022
BackgroundThere is an epidemic of firearm injuries in the United States since the mid-2000s. Thus, we sought to examine whether hospitalization from...
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Leveraging machine learning for predicting acute graft-versus-host disease grades in allogeneic hematopoietic cell transplantation for T-cell prolymphocytic leukaemia
Orphan diseases, exemplified by T-cell prolymphocytic leukemia, present inherent challenges due to limited data availability and complexities in...
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An evaluation of computational methods for aggregate data meta-analyses of diagnostic test accuracy studies
BackgroundA Generalized Linear Mixed Model (GLMM) is recommended to meta-analyze diagnostic test accuracy studies (DTAs) based on aggregate or...
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Weibull parametric model for survival analysis in women with endometrial cancer using clinical and T2-weighted MRI radiomic features
BackgroundSemiparametric survival analysis such as the Cox proportional hazards (CPH) regression model is commonly employed in endometrial cancer...
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Machine learning models for abstract screening task - A systematic literature review application for health economics and outcome research
ObjectiveSystematic literature reviews (SLRs) are critical for life-science research. However, the manual selection and retrieval of relevant...
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Using Bayesian statistics in confirmatory clinical trials in the regulatory setting: a tutorial review
Bayesian statistics plays a pivotal role in advancing medical science by enabling healthcare companies, regulators, and stakeholders to assess the...
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Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis
BackgroundDuring the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies.
Objective ...
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A novel non-negative Bayesian stacking modeling method for Cancer survival prediction using high-dimensional omics data
BackgroundSurvival prediction using high-dimensional molecular data is a hot topic in the field of genomics and precision medicine, especially for...
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Propensity score analysis for health care disparities: a deweighting approach
BackgroundPropensity score weighting is a useful tool to make causal or unconfounded comparisons between groups. According to the definition by the...
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Missingness mechanisms and generalizability of patient reported outcome measures in colorectal cancer survivors – assessing the reasonableness of the “missing completely at random” assumption
BackgroundPatient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and...
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The establishment of a multiple myeloma clinical registry in the Asia–Pacific region: The Asia–Pacific Myeloma and Related Diseases Registry (APAC MRDR)
BackgroundMultiple myeloma (MM) is the second most common haematological cancer worldwide. Along with related diseases including monoclonal...
