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Constructing diagnostic signature of serum microRNAs using machine learning for early pan-cancer detection
BackgroundCancer is a major public health concern and the second leading cause of death worldwide. Various studies have reported the use of serum...
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Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was...
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Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives
Liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death in the world, and hepatocellular carcinoma (HCC)...
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Bibliometric and visual analysis in the field of two-dimensions nano black phosphorus in cancer from 2015 to 2023
This study aims to provide a comprehensive summary of the status and trends of Two-Dimensional Nano Black Phosphorus (2D nano BP) in cancer research...
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Prognostic value of oxidative phosphorylation-related genes in hepatocellular carcinoma
PurposeHepatocellular carcinoma (HCC) is the most prevalent malignancies worldwide. Recently, oxidative phosphorylation (OXPHOS) has received...
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Integrated pan-cancer and scRNA-seq analyses identify a prognostic coagulation-related gene signature associated with tumor microenvironment in lower-grade glioma
Cancer-associated thrombosis is a significant complication in cancer patients, leading to increased morbidity and mortality. The expression of...
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TCBIR/CD320: a potential therapeutic target upregulated in endothelial cells and associated with immune cell infiltration in liver hepatocellular carcinoma
CD320, which is a transmembrane protein responsible for facilitating the absorption of vitamin B12, plays a key role in this process. However, the...
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Systemtherapie des Magenkarzinoms im Stadium IV – aktuelle Entwicklungen
BackgroundSystemic treatment of metastatic or unresectable gastric cancer, including esophagogastric junction adenocarcinoma, has developed since...
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Pancreatic cancer cell- and cancer-associated fibroblast-derived exosomes in disease progression, metastasis, and therapy
Exosomes play a crucial role in the progression and spread of pancreatic cancer, serving not only as promoters of tumor growth and organ-specific...
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Single-Center Randomized Trial Comparing Feeding Jejunostomy with Nasojejunal Tube Placement in Patients Undergoing Transhiatal Esophagectomy Post-Neoadjuvant Therapy for Esophageal Cancer
BackgroundEnteral nutrition is the preferred mode of nutrition following esophagectomy. However, the preferred mode of enteral nutrition (feeding...
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Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer
PurposeTreatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a...
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The value of 68Ga-PSMA PET/CT in the diagnosis of intracapsular prostate cancer with a poor prognosis
ObjectiveTo evaluate the diagnostic value of 68 Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography...
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Tolerance of radiotherapy with concomitant glofitamab in diffuse large B cell lymphoma: a case report
Glofitamab, an anti-CD20 antibody, is approved as a third-line treatment for relapsed or refractory (r/r) diffuse large-cell B lymphoma (DLBCL),...
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Characterization of accurate 3D collimator-detector response function for single- and multi-lofthole collimated SPECT cameras
PurposeCollimator-detector response function (CDRF) of a SPECT scanner refers to the image generated from a point source of activity. This research...
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Integrating molecular pathway with genome-wide association data for causality identification in breast cancer
ObjectiveThe study purpose was to explore the causal association between pyruvate metabolism and breast cancer (BC), as well as the molecular role of...
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Targeting SEZ6L2 in Colon Cancer: Efficacy of Bexarotene and Implications for Survival
BackgroundBexarotene, also recognized as Targretin, is categorized as a retinoid, a type of cancer drug. Nevertheless, the precise mechanisms of...
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Diagnostic performances of GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro in “Diagnosis Please” cases
PurposeLarge language models (LLMs) are rapidly advancing and demonstrating high performance in understanding textual information, suggesting...
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CT colonography has advantages over colonoscopy for size measurement of colorectal polyps
PurposeThe aim of this study was to compare the accuracy of colonoscopy (CS) and CT colonography (CTC) in the measurement of colorectal polyps using...
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Long-term outcomes of high-dose-rate brachytherapy and external beam radiotherapy without hormone therapy for high-risk localized prostate cancer
PurposeUntil March 2018, patients with high-risk localized prostate cancer had been administered high-dose-rate brachytherapy (HDR-BT) combined with...
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Identification of placenta-specific protein 1 (PLAC-1) expression on human PC-3 cell line-derived prostate cancer stem cells compared to the tumor parental cells
Placenta-specific protein 1 (PLAC-1) is a gene primarily expressed in the placenta and the testis. Interestingly, it is also found to be expressed in...
