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Muscle MRI as a biomarker of disease activity and progression in myotonic dystrophy type 1: a longitudinal study
IntroductionMyotonic dystrophy type 1 (DM1) is an autosomal dominant disease characterized by myotonia and progressive muscular weakness and atrophy....
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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought...
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The brachioradialis longus: an unreported accessory form of the brachioradialis muscle
The brachioradialis muscle (BR) belongs to the lateral forearm muscle. Typically, the radial nerve innervates it. BR morphological variability, such...
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Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic
During the Covid-19 pandemic Germany experienced its first increase in the proportion of heavy cannabis users since 1995. With the expected...
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Aticaprant, a kappa opioid receptor antagonist, and the recovered ‘interest and pleasure’ in the concept of major depressive disorder
Lack of positive mood and anhedonia probably are the most specific depressive symptoms. Anhedonia is a multifaceted concept: the clinical language...
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Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
IntroductionIn 2023, the German Society of Neurology published a new guideline on Parkinson’s disease. An important section dealt with PD care...
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What Chemsex does to the brain - neural correlates (ERP) regarding decision making, impulsivity and hypersexuality
Chemsex describes the use of specific substances (methamphetamine, GHB/GBL, mephedrone, ketamine) which initiate or enhance sexual experiences and is...
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression
Previous studies have shown an association between the thalamocortical dysconnectivity and treatment-resistant depression (TRD). Whether a single...
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Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI
Objective: The clinical manifestations of methamphetamine (METH)-associated psychosis (MAP) and acute paranoid schizophrenia (SCZ) are similar. This...
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Individualized time windows enhance TMS-EEG signal characterization and improve assessment of cortical function in schizophrenia
Transcranial magnetic stimulation and electroencephalography (TMS-EEG) recordings are crucial to directly assess cortical excitability and inhibition...
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Second-look surgery in postoperative pediatric low-grade glioma
ObjectiveTo review the literature on second-look surgery in pediatric low-grade gliomas (LGG) with a view to presenting both sides of the picture of...
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Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients
BackgroundNeuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally.
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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Fatigue in multiple sclerosis: can we measure it and can we treat it?
Fatigue is a common and debilitating symptom in multiple sclerosis (MS). However, after over 100 years of inquiry its definition, measurement and...
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Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson’s disease with depression: a comprehensive analysis
Brain-derived neurotrophic factor (BDNF) and glycolipid metabolism have been implicated in cognitive impairments and depression among Parkinson’s...
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Monotherapy with infusion therapies – useful or not?
Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with...
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Evaluation of 3D T1-weighted spoiled gradient echo MR image quality using artificial intelligence image reconstruction techniques in the pediatric brain
PurposeTo assess image quality and diagnostic confidence of 3D T1-weighted spoiled gradient echo (SPGR) MRI using artificial intelligence (AI)...
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Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6
BackgroundWhile mechanical thrombectomy is considered standard of care for large vessel occlusions, scientific evidence to support treatment for...
