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Ruxolitinib Cream in Adolescents/Adults with Atopic Dermatitis Meeting Severity Thresholds for Systemic Therapy: Exploratory Analysis of Pooled Results from Two Phase 3 Studies
IntroductionStandard therapy for patients with mild to moderate atopic dermatitis (AD) typically includes topical therapies; however, patients with...
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Comparative analysis of reduced toxicity conditioning regimens between fludarabine plus melphalan and fludarabine plus busulfex in adult patients with acute lymphoblastic leukemia
Reduced-toxicity conditioning (RTC) regimens aim to mitigate regimen-related toxicity while maintaining anti-leukemic efficacy in allogeneic...
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Mucinous tubular and spindle renal cell carcinoma revealed by a trauma of the kidney: a case report
BackgroundMucinous tubular and spindle cell carcinoma is a rare renal tumor. It has been recognized as a distinct entity in the 2004 World Health...
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Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial
BackgroundChronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has...
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The value of deep learning-based X-ray techniques in detecting and classifying K-L grades of knee osteoarthritis: a systematic review and meta-analysis
ObjectivesKnee osteoarthritis (KOA), a prevalent degenerative joint disease, is primarily diagnosed through X-ray imaging. The Kellgren-Lawrence...
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Assessing ChatGPT’s theoretical knowledge and prescriptive accuracy in bacterial infections: a comparative study with infectious diseases residents and specialists
ObjectivesAdvancements in Artificial Intelligence(AI) have made platforms like ChatGPT increasingly relevant in medicine. This study assesses...
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Use of Cefiderocol in Adult Patients: Descriptive Analysis from a Prospective, Multicenter, Cohort Study
IntroductionCefiderocol is a siderophore cephalosporin showing activity against various carbapenem-resistant Gram-negative bacteria (CR-GNB). No data...
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Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
PurposeContinuous positive airway pressure (CPAP) is the primary therapy for obstructive sleep apnea (OSA); however the effectiveness of CPAP remains...
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Clinical Application of Different Doses of Hydromorphone Slow-Release Analgesia in Lumbar Fusion in Elderly Patients
IntroductionThe aim of this study is to examine the analgesic efficacy of varying doses of hydromorphone hydrochloride in conjunction with absorbable...
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Gastric bezoars secondary to mixed infection with Sarcina ventriculi and G + bacilli: a case report
Sarcina ventriculi is a bacterium with a specific histological morphology and infection can present with symptoms such as abdominal pain, nausea,...
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Unlocking the therapeutic potential of Nigella sativa extract: phytochemical analysis and revealing antimicrobial and antioxidant marvels
The growing global threat of antimicrobial resistance endangers both human and animal life, necessitating the urgent discovery of novel antimicrobial...
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Dapagliflozin, inflammation and left ventricular remodelling in patients with type 2 diabetes and left ventricular hypertrophy
Background and AimsSodium-glucose co-transporter 2 (SGLT2) inhibitors have beneficial effects in heart failure (HF), including reverse remodelling,...
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Analyzing the molecular mechanism of Scutellaria Radix in the treatment of sepsis using RNA sequencing
BackgroundSepsis is a life-threatening organ dysfunction, which seriously threatens human health. The clinical and experimental results have...
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Diagnostic performance of ADC and ADCratio in MRI-based prostate cancer assessment: A systematic review and meta-analysis
ObjectivesTo identify factors influencing the diagnostic performance of the quantitative imaging biomarkers ADC and ADCratio in prostate cancer (PCa)...
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Mammographic features differ with body composition in women with breast cancer
ObjectivesThere are several breast cancer (BC) risk factors—many related to body composition, hormonal status, and fertility patterns. However, it is...
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The Role of Widefield Optical Coherence Tomography Angiography in Assessing the Severity of Diabetic Retinopathy
IntroductionPhysicians need an accurate understanding of diabetic retinopathy (DR) severity to optimally manage patients. The aim of this prospective...
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Sonological predictors of complications of percutaneous renal biopsy—a prospective observational study
AbstractPercutaneous renal biopsy, although essential for renal disease diagnosis, is associated with a number of post-biopsy complications ranging...