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Interrelationship between thyroid hormones and reduced renal function, a review article
BackgroundUnderstanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications...
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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...
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Map** alternative splicing events in colorectal cancer
Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...
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Comparison of the dosimetry of scandium-43 and scandium-44 patient organ doses in relation to commonly used gallium-68 for imaging neuroendocrine tumours
BackgroundSeveral research groups have explored the potential of scandium radionuclides for theragnostic applications due to their longer half-lives...
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Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia
Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 10 9 /l after...
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Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses
BackgroundNivolumab monotherapy is the standard second-line treatment for advanced esophageal squamous cell carcinoma (ESCC) after failure of...
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Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice
PurposeFibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain...
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ACTH-producing adrenocortical carcinoma: an exceedingly rare diagnosis
BackgroundAdrenocortical carcinoma is a very rare endocrinopathy that has a poor prognosis and is frequently associated with ACTH-independent...
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Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience
BackgroundAdvanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...
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Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study
The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for...
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FDG altered biodistribution in white adipose tissue, a rare entity: case report and review of the literature
PurposeAltered 18 F-fluorodeoxyglucose (FDG) biodistribution due to patient factors such as exercise and inadequate fasting are well established...
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Deep transfer learning for detection of breast arterial calcifications on mammograms: a comparative study
IntroductionBreast arterial calcifications (BAC) are common incidental findings on routine mammograms, which have been suggested as a sex-specific...
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YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential...
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Impact of rehabilitation unit-based physical activity therapy versus symptomatic supportive treatment on older patients with advanced cancer: a non-randomized controlled study
ObjectivesRelatively few studies have investigated the effects of rehabilitation-based physical activity therapy as a treatment for older patients...
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Evaluation of a novel 177Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
PurposeFusion of Affibody molecules with an albumin-binding domain (ABD) provides targeting agents, which are suitable for radionuclide therapy. To...
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Pareto optimization of SPECT acquisition and reconstruction settings for 177Lu activity quantification
BackgroundThe aim was to investigate the noise and bias properties of quantitative 177 Lu-SPECT with respect to the number of projection angles, and...
