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Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
BackgroundCholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1...
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A rare case of hepatic hydatid cyst in Somalia: a case report
BackgroundEchinococcosis, or hydatid disease, is caused by the larval forms of taeniid cestodes belonging to the genus Echinococcus . Echinococcus...
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“Just for pregnant women, not for you”: a qualitative evaluation of the sexual and reproductive healthcare experiences of transgender and gender diverse cancer survivors
PurposeTo identify opportunities to improve sexual and reproductive health (SRH) care for transgender and gender diverse (TGD) cancer survivors by...
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Kathetergestützte lokale Lysetherapie bei submassiven Lungenembolien
BackgroundPulmonary embolism is the third most common cardiovascular disease. Interventional treatment options as an alternative to systemic lysis...
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A BRILLIANT-BRCA study: residual breast tissue after mastectomy and reconstruction
IntroductionDifferent types of mastectomies leave different amounts of residual breast tissue. The significance of the residual breast volume (RBV)...
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[18F]-D3FSP β-amyloid PET imaging in older adults and alzheimer’s disease
Purpose[ 18 F]-D3FSP is a new β-amyloid (Aβ) PET imaging tracer designed to decrease nonspecific signals in the brain by reducing the formation of the...
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Duloxetine to prevent neuropathy in breast cancer patients under paclitaxel chemotherapy (a double-blind randomized trial)
PurposeChemotherapy-induced peripheral neuropathy (CIPN) is one of the major side effects and main reasons for affecting quality of life and dose...
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Chemotherapy’s effects on autophagy in the treatment of Hodgkin’s lymphoma: a sco** review
BackgroundClassical Hodgkin Lymphomas (HL) are a unique malignant growth with an excellent initial prognosis. However, 10–30% of patients will still...
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Prospective investigation of amino acid transport and PSMA-targeted positron emission tomography for metastatic lobular breast carcinoma
PurposeTo explore the feasibility of imaging amino-acid transport and PSMA molecular pathways in the detection of metastatic breast invasive lobular...
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The role of anti-citrullinated protein antibody in pathogenesis of RA
Rheumatoid arthritis (RA) is a common autoimmune rheumatic disease that causes chronic synovitis, bone erosion, and joint destruction. The...
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Helicobacter pylori ( H. pylori ) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high...
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Impacts of X-linked Retinitis Pigmentosa and Patient Pathways in European Countries: Results from the Cross-sectional EXPLORE XLRP-1 Physician Survey
IntroductionX-linked retinitis pigmentosa (XLRP) is a rare, incurable, vision-threatening, genetic disease. In this study, we aimed to reveal the...
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Effects of the subtypes of apolipoprotein E on immune inhibition and prognosis in patients with Hepatocellular Carcinoma
PurposeTo investigate whether prognosis of patients with hepatocellular carcinoma (HCC) is affected by the abundance and subgroups of myeloid-derived...
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FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
ObjectiveGlioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer...
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Increased Risk of Severe Cardiovascular Events Following Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the EXACOS-CV Study in Japan
IntroductionSevere exacerbations of chronic obstructive pulmonary disease (COPD) are known to increase the risk of cardiovascular events. However,...
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Usability of the SB11 Pre-filled Syringe (PFS) in Patients with Retinal Diseases
IntroductionSB11 (Byooviz™; Samsung Bioepis Co., Ltd.) is a ranibizumab (Lucentis ® ; Genentech, Inc.) biosimilar targeting vascular endothelial...
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Similar genetic profile in early and late stage urothelial tract cancer
IntroductionUrothelial tract cancer (UTC) ranks as the tenth most prevalent cancer and holds the seventh position in terms of mortality worldwide....
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Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds
Purpose of ReviewThe global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects...