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Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Previous studies that focused on univariate correlations between neuroanatomy and cognition in schizophrenia identified some inconsistent findings....
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Intracranial dissemination of Klebsiella pneumoniae originating from pulmonary infection: a case report
BackgroundMetastatic brain abscesses caused by Klebsiella pneumoniae are extremely rare but life-threatening conditions. To depict a unique case of...
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Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research
Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new...
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Plasma Biomarkers of Alzheimer’s Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions
Ultrasensitive assays have been developed which enable biomarkers of Alzheimer’s disease pathology and neurodegeneration to be measured in blood....
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Doing a double take: when transthoracic echocardiography fails for mitral valve annuloplasty ring endocarditis with Streptococcus pyogenes: a case report
BackgroundThis case highlights several complications of a late and rare presentation of culture-negative Streptococcus pyogenes endocarditis of a...
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Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults
ObjectiveThe objective of this study was to develop a risk prediction model for motoric cognitive risk syndrome (MCR) in older adults.
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Benefits of a family-based care transition program for older adults after hip fracture surgery
BackgroundHip fracture (HF) in older adults is strongly associated with a greater decline in their activities of daily living (ADLs) and...
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has...
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Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis
Background and objectivesIn multiple sclerosis (MS), slowly expanding lesions were shown to be associated with worse disability and prognosis. Their...
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Patients with complex and very-early-onset ATL1-related spastic paraplegia offer insights on genotype/phenotype correlations and support for autosomal recessive forms of SPG3A
Spastic paraplegia type 3A (SPG3A) is the second most common form of hereditary spastic paraplegia (HSP). This autosomal-dominant-inherited motor...
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Multiple lung abscesses and cold agglutinin syndrome following coronavirus disease 2019: a case report
BackgroundCold agglutination syndrome is a subtype of autoimmune hemolytic anemia. The condition is referred to as “cold” because the antibodies...
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Esketamine in depression: putative biomarkers from clinical research
The discovery of racemic ( R , S )-ketamine as a rapid-acting antidepressant and the subsequent FDA approval of its ( S )-enantiomer, esketamine, for...
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Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis
Common psychiatric disorders constitute one of the most substantial healthcare burdens worldwide. However, drug development in psychiatry remains...
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Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
Neuroligin-3 ( Nlgn3 ) is an autism-associated cell-adhesion molecule that interacts with neurexins and is robustly expressed in both neurons and...
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Surgical strategy in treatment of metopic synostosis in a single centre experience: technical note and quantitative analysis of the outcomes
PurposeTrigonocephaly is the most common craniosynostosis involving orbits. Although some degree of agreement has been reached regarding surgical...
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Automated classification of brain MRI reports using fine-tuned large language models
PurposeThis study aimed to investigate the efficacy of fine-tuned large language models (LLM) in classifying brain MRI reports into pretreatment,...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
