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Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats
BackgroundEpisodes of recurrent or severe hypoglycemia can occur in patients with diabetes mellitus, insulinoma, neonatal hypoglycemia, and...
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Safety and Psychological Outcomes of Tandem t:Slim X2 Insulin Pump with Control-IQ Technology in Children, Adolescents, and Young Adults with Type 1 Diabetes: A Systematic Review
The Tandem t:slim X2 insulin pump is a second-generation automated insulin delivery system with Control-IQ technology. It consists of an X2 insulin...
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Tirzepatide Improved Health-Related Quality of Life Compared with Insulin Lispro in Basal Insulin-Treated Adults with Type 2 Diabetes and Inadequate Glycaemic Control: A Randomised Controlled Phase 3b Trial (SURPASS-6)
IntroductionPatients with type 2 diabetes (T2D) who require intensification of basal insulin therapy need treatment options that can improve their...
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Association of Changes in A1C Following Continuous Glucose Monitoring Acquisition in People with Sub-Optimally Treated Type 2 Diabetes Taking GLP-1 RA Therapy
IntroductionBoth glucagon-like peptide-1 receptor agonists (GLP-1 RA) and continuous glucose monitoring (CGM) improve glycemia in patients with type...
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Comparison of four confirmatory tests for the diagnosis of primary aldosteronism: Bayesian analysis in the absence of a gold standard
BackgroundCaptopril challenge test (CCT), seated saline infusion test (SSIT), oral sodium loading test (OSLT) and fludrocortisone suppression test...
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Assessment of glycemic susceptibility across multiple urological and reproductive disorders
ObjectiveTo test the glycemic susceptibility in three urological cancers and eight urological/reproductive diseases using the Mendelian randomization...
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Predictors of response to Radioactive Iodine Therapy in Intermediate and high risk patients with papillary thyroid carcinoma
BackgroundRadioactive iodine (RAI) therapy is the standard treatment approach after total thyroidectomy in patients with papillary thyroid carcinoma...
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ISIS 449884 Injection Add-On to Metformin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase II Clinical Study
IntroductionISIS 449884, a 2′- O -methoxyethyl antisense oligonucleotide that targets the glucagon receptor (GCGR), has demonstrated an ability to...
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Comparison of clinical characteristics and treatment outcomes between initially diagnosed type 1 and type 2 diabetes mellitus patients presenting with diabetic ketoacidosis
ObjectivePatients with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) can present with diabetic ketoacidosis (DKA) as the first manifestation....
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A comparison of brown fat tissue related hormone levels in metabolically healthy and unhealthy individuals with obesity
PurposeOne of the key functions of brown adipose tissue is its positive impact on metabolism. This study aimed to examine the potential involvement...
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The potential anti-arrhythmic effect of SGLT2 inhibitors
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by...
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Treatment and management of medullary thyroid microcarcinoma: a 10-year retrospective study from a single center
ObjectiveTo explore individualized treatment and management methods for medullary thyroid microcarcinoma (MTMC).
MethodsClinical data of patients...
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The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population
BackgroundWaist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation...
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A novel nomogram for predicting the risk of persistent hyperparathyroidism after kidney transplantation
PurposePersistent hyperparathyroidism (PTHPT) in kidney transplant recipients is associated with bone loss, graft dysfunction and cardiovascular...
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Effective strategies for pregnancy and lactation-associated osteoporosis: teriparatide use in focus
IntroductionPregnancy and lactation-associated osteoporosis (PLO) is a rare condition characterized by fragility fractures occurring during late...
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Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?
Purpose of ReviewThis review aims to critically examine how VLCKD affects plasma lipoprotein, lipid and cholesterol metabolism. Cardiovascular...
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Early changes of microRNAs in blood one month after bariatric surgery
BackgroundChanges in microRNAs (miRNAs) are relevant to bariatric surgery and its comorbidities. The characteristics of changes in miRNAs of the...
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Oncological features of sporadic vs. hereditary pediatric medullary thyroid cancer
PurposeNo genomic data have been put forth that prove beyond a shadow of doubt that sporadic medullary thyroid cancer (MTC) occurs in infancy,...
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Clinicopathological spectrum, management, and outcome of ectopic parathyroid carcinoma: Experience with 24 cases
PurposeEctopic parathyroid carcinoma (EPC) is a rare clinical entity with multiple diagnostic pitfalls, making surgical cures challenging. We...
