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SARS-CoV-2 seropositivity in African women living with HIV and their infants
BackgroundSARS-CoV-2 seropositivity data in women living with HIV (WLHIV), their infants and associated factors in this subpopulation remain limited....
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CT radiomics combined with clinical and radiological factors predict hematoma expansion in hypertensive intracerebral hemorrhage
ObjectivesThis study aimed to establish a hematoma expansion (HE) prediction model for hypertensive intracerebral hemorrhage (HICH) patients by...
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Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma
BackgroundTherapeutic approach used for pancreatic ductal adenocarcinoma is usually translated also for the rarer acinar counterpart, which shows a...
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Breast lesions on MRI in mass and non-mass enhancement: Kaiser score and modified Kaiser score + for readers of variable experience
ObjectivesTo compare the diagnostic performance of three readers using BI-RADS and Kaiser score (KS) based on mass and non-mass enhancement (NME)...
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Incompatibility of the short-acting benzodiazepine remimazolam with common perioperative medication
BackgroundRemimazolam is a relatively new benzodiazepine with growing use in procedural sedation and general anaesthesia. Initiated by case reports,...
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Straight intramedullary MultiLoc nails for displaced proximal humeral fractures: health status, radiographic results, clinical outcome, and complications
BackgroundThe treatment of the displaced proximal humerus fractures (PHF) still facing a lot of unsolved problems. The aim of this study was to...
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Distinctive protein expression in elderly livers in a Sprague–Dawley rat model of normothermic ex vivo liver machine perfusion
BackgroundLiver grafts are frequently declined due to high donor age or age mismatch with the recipient. To improve the outcome of marginal grafts,...
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Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging
PurposeFrailty is a common health state that is closely linked to adverse health outcomes in aging society. Although many inflammatory biomarkers...
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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing...
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Effect of the Sauvé–Kapandji method on the wrist contact surface for distal radial ulnar joint disorders
BackgroundThe Sauvé–Kapandji (S-K) method is a surgical procedure performed for chronic deformities of the distal radial ulnar joint (DRUJ). Changes...
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A double CYP27A1 gene mutation in spinal cerebrotendinous xanthomatosis in a patient presenting with spastic gait: a case report
BackgroundCerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene....
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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Impact of the ActTeens Program on physical activity and fitness in adolescents: a cluster randomized controlled trial
BackgroundThe aim of our study was to evaluate the impact of the ActTeens Program on physical activity and health-related physical fitness among...
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Off-pump Versus On-pump Coronary Artery Bypass Grafting in Diabetic patients: A Meta-analysis of Observational Studies with a Propensity-Score Analysis
PurposeThe debate between off-pump coronary artery bypass grafting (OPCAB) and on-pump coronary artery bypass grafting (ONCAB) in diabetic patients...
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89Zr-immunoPET-guided selection of a CD33xIL15 fusion protein optimized for antitumor immune cell activation and in vivo tumour retention in acute myeloid leukaemia
PurposeImmune cells are capable of eliminating leukemic cells, as evidenced by outcomes in hematopoietic cell transplantation (HCT). However,...
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Optimizing coronary CT angiography quality with motion-compensated reconstruction for second-generation dual-layer spectral detector CT
ObjectivesTo investigate the effect of motion-compensated reconstruction (MCR) algorithm on improving the image quality of coronary computed...
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Causal impact of statins on susceptibility to osteoarthritis: insights from a two-sample Mendelian randomization analysis
BackgroundOsteoarthritis is a widely prevalent cause of pain and disability among older adults. It is an incurable condition, and most treatments are...
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Cost-effectiveness analysis of amivantamab plus chemotherapy for non-small cell lung cancer patients with epidermal growth factor receptor exon 20 insertions in the United States
BackgroundAlthough amivantamab has shown clinical benefits for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor...
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Integrated network pharmacology and metabolomics to reveal the mechanism of Pinellia ternata inhibiting non-small cell lung cancer cells
Lung cancer is a malignant tumor with highly heterogeneous characteristics. A classic Chinese medicine, Pinellia ternata (PT), was shown to exert...
