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Key performance indicators in pre-hospital response to disasters and mass casualty incidents: a sco** review
PurposeThe objective of this study was to offer a comprehensive synthesis of the existing Key performance indicators (KPIs) used in the evaluation of...
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A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
PurposeIn exposure–response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are often aggregated into a single...
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Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis
PurposeOptimal oxygenation targets for patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are not clearly defined due...
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Survival after thermal ablation versus wedge resection for stage I non-small cell lung cancer < 1 cm and 1 to 2 cm: evidence from the US SEER database
BackgroundThis study compared the survival outcomes after thermal ablation versus wedge resection in patients with stage I non-small cell lung cancer...
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Genetic and clinical characteristics of acute B-cell lymphoblastic leukemia with MEF2D fusions and report of two novel MEF2D rearrangements
The MEF2D rearrangement is a recurrent chromosomal abnormality detected in approximately 2.4–5.3% of patients with acute B-cell lymphoblastic...
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Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma
BackgroundTherapeutic approach used for pancreatic ductal adenocarcinoma is usually translated also for the rarer acinar counterpart, which shows a...
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DCE-MRI to distinguish all monoclonal plasma cell disease stages and correlation with diffusion-weighted MRI/PET-based biomarkers in a hybrid simultaneous whole body-2-[18F]FDG-PET/MRI imaging approach
BackgroundDynamic contrast-enhanced-MRI (DCE-MRI) is able to study bone marrow angiogenesis in patients with multiple myeloma (MM) and asymptomatic...
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Burden of illness in patients with pulmonary hypertension due to interstitial lung disease: a real-world analysis
BackgroundPulmonary hypertension due to interstitial lung disease (PH-ILD) is associated with high rates of respiratory failure and death. Healthcare...
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The paradox of workplace violence in the intensive care unit: a focus group study
BackgroundConflicts with patients and relatives occur frequently in intensive care units (ICUs), driven by factors that are intensified by critical...
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Commentary on the “A multidisciplinary opioid-reduction pathway for robotic prostatectomy: outcomes at year one”
BackgroundOpioid-sparing multimodal analgesia is increasingly emphasized for postoperative pain management. This commentary discusses a study by...
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Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study)
BackgroundThe objective of this study was to analyze the effects of sedation administration on clinical parameters, comfort status, intubation...
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Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion
Acute myeloid leukemia (AML) is an aggressive and genetically heterogeneous disease with poor clinical outcomes. Refractory AML is common, and...
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Incompatibility of the short-acting benzodiazepine remimazolam with common perioperative medication
BackgroundRemimazolam is a relatively new benzodiazepine with growing use in procedural sedation and general anaesthesia. Initiated by case reports,...
