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The association between screen time exposure, parent depression, and development of social communication skills among preschool children in Qassim Region
BackgroundScreen exposure among children continues to increase worldwide. It has negative effects on children of developmental age, including...
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Towards an informed research agenda for the field of personality disorders by experts with lived and living experience and researchers
BackgroundWe describe a collection of themes for a research agenda for personality disorders that was originally formulated for the ESSPD Borderline...
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Spinal muscular atrophy caused by compound heterozygous SMN1 mutations: two cases and literature review
Spinal muscular atrophy (SMA) is a rare neuromuscular disease, which is characterized by the degeneration of motor neurons, leading to symmetrical...
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Applications of machine learning to MR imaging of pediatric low-grade gliomas
IntroductionMachine learning (ML) shows promise for the automation of routine tasks related to the treatment of pediatric low-grade gliomas (pLGG)...
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Muscle MRI as a biomarker of disease activity and progression in myotonic dystrophy type 1: a longitudinal study
IntroductionMyotonic dystrophy type 1 (DM1) is an autosomal dominant disease characterized by myotonia and progressive muscular weakness and atrophy....
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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought...
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The brachioradialis longus: an unreported accessory form of the brachioradialis muscle
The brachioradialis muscle (BR) belongs to the lateral forearm muscle. Typically, the radial nerve innervates it. BR morphological variability, such...
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Phenotypic and mutational spectrum of 17 Chinese patients with Menkes Disease
BackgroundMenkes Disease (MD) is a fatal X-linked recessive disorder caused by mutations in the ATP7A gene. Severe cases typically die before the age...
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Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic
During the Covid-19 pandemic Germany experienced its first increase in the proportion of heavy cannabis users since 1995. With the expected...
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Aticaprant, a kappa opioid receptor antagonist, and the recovered ‘interest and pleasure’ in the concept of major depressive disorder
Lack of positive mood and anhedonia probably are the most specific depressive symptoms. Anhedonia is a multifaceted concept: the clinical language...
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Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
IntroductionIn 2023, the German Society of Neurology published a new guideline on Parkinson’s disease. An important section dealt with PD care...
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What Chemsex does to the brain - neural correlates (ERP) regarding decision making, impulsivity and hypersexuality
Chemsex describes the use of specific substances (methamphetamine, GHB/GBL, mephedrone, ketamine) which initiate or enhance sexual experiences and is...
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression
Previous studies have shown an association between the thalamocortical dysconnectivity and treatment-resistant depression (TRD). Whether a single...
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Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial
SNT is a high-dose accelerated intermittent theta-burst stimulation (iTBS) protocol coupled with functional-connectivity-guided targeting that is an...
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Successful treatment with efgartigimod as an add-on therapy in acute attack of anti-AQP4 antibody-positive NMOSD: a case report
BackgroundNeuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune demyelinating disease characterized by recurrent myelitis and optic...
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Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI
Objective: The clinical manifestations of methamphetamine (METH)-associated psychosis (MAP) and acute paranoid schizophrenia (SCZ) are similar. This...
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Targeting Neurotransmitter Systems in Bipolar Disorder: A comprehensive Review of novel pharmacological approaches
Purpose of ReviewTo critically assess the efficacy of novel pharmacological interventions in managing manic or hypomanic episodes in adult patients...
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Individualized time windows enhance TMS-EEG signal characterization and improve assessment of cortical function in schizophrenia
Transcranial magnetic stimulation and electroencephalography (TMS-EEG) recordings are crucial to directly assess cortical excitability and inhibition...
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Second-look surgery in postoperative pediatric low-grade glioma
ObjectiveTo review the literature on second-look surgery in pediatric low-grade gliomas (LGG) with a view to presenting both sides of the picture of...
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Late adolescent outcomes of different developmental trajectories of ADHD symptoms in a large longitudinal study
There exists substantial heterogeneity in the developmental trajectories of ADHD symptoms, with distinctions often made between persistent versus...