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Prompt closure versus gradual weaning of external ventricular drain for hydrocephalus following aneurysmal subarachnoid haemorrhage: a statistical analysis plan for the DRAIN randomised clinical trial
BackgroundInsertion of an external ventricular drain (EVD) is a first-line treatment of acute hydrocephalus caused by aneurysmal subarachnoid...
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Theory of change for addressing sex and gender bias, invisibility and exclusion in Australian health and medical research, policy and practice
Sex and gender are inadequately considered in health and medical research, policy and practice, leading to preventable disparities in health and...
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A protocol for the formative evaluation of the implementation of patient-reported outcome measures in child and adolescent mental health services as part of a learning health system
BackgroundMental health conditions affect one in seven young people and research suggests that current mental health services are not meeting the...
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The challenges of assessing adiposity in a clinical setting
To tackle the burden of obesity-induced cardiometabolic disease, the scientific community relies on accurate and reproducible adiposity measurements...
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Prenatal affective cognitive training to reduce the risk of postpartum depression (PACT): study protocol for a randomized controlled trial
BackgroundPostpartum depression (PPD) affects 30–50% of women with a history of previous depression or bipolar disorder and 8% of women with no...
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Perception of couples’ on multipurpose prevention technology attribute choice: the case of MTN 045
BackgroundMultipurpose prevention technologies (MPTs) are products capable of simultaneously addressing multiple sexual and reproductive health needs...
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Capturing the HIV-related social exclusion practices experienced by key populations through photovoice: an interpretative phenomenological study
BackgroundKey populations are defined as groups that are susceptible to HIV, including Men Sex with Men (MSM), Transgender (TG), Persons who Inject...
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Risk factors for persistent fatal opioid-involved overdose clusters in Massachusetts 2011–2021: a spatial statistical analysis with socio-economic, accessibility, and prescription factors
BackgroundFatal opioid-involved overdose rates increased precipitously from 5.0 per 100,000 population to 33.5 in Massachusetts between 1999 and 2022.
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Short-term S100A8/A9 Blockade Promotes Cardiac Neovascularization after Myocardial Infarction
Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms...
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Global prevalence and predictors of scabies among prisoners: systematic review and meta-analysis
IntroductionScabies is a widespread issue in prisons due to overcrowded living conditions and limited healthcare resources. A recent study published...
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Inositols and female reproduction disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—Women’s Endocrinology
PurposeTo provide the latest scientific knowledge on the efficacy of inositols for improving reproductive disorders in women with and without...
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Efficacy of iron supplementation on physical capacity in non-anaemic iron-deficient individuals: protocol for an individual patient data meta-analysis
BackgroundA deficiency in iron stores is associated with various adverse health complications, which, if left untreated, can progress to states of...
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Association of diastolic blood pressure with coronary perfusion pressure during resuscitation in pediatric swine
BackgroundDiastolic blood pressure (DBP) is suggested as a surrogate for coronary perfusion pressure (CPP) during cardiopulmonary resuscitation. We...
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Projection of the prevalence of tracheal, bronchus, and lung cancer incidence using cigarette smoking prevalence in Iran from 1990 to 2018: a comparison of latent period-based models with standard forecasting models
BackgroundSmoking is the major risk factor for tracheal, bronchus, and lung (TBL) cancers. We investigated the feasibility of projecting TBL cancer...
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Mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk
The mitochondrial cascade hypothesis of Alzheimer’s disease (AD) has been portrayed through molecular, cellular, and animal studies; however large...
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The abortion trend after the pronatalist turn of population policies in Iran: a systematic review from 2005 to 2022
ObjectiveGiven Iran’s recent shift towards pronatalist population policies, concerns have arisen regarding the potential increase in abortion rates....
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A multidisciplinary group-based survivorship intervention for those living with multiple myeloma: a feasibility study
BackgroundWhile multiple myeloma continues to be an incurable cancer, advances in its understanding and management have led to significantly improved...
