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Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art
Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials in...
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Survey on pattern of myopia in school children in Hangzhou after the COVID-19 pandemic: a school-based vision screening study
BackgroundMyopia is a major health issue around the world. Myopia in children has increased significantly during the COVID-19 pandemic in China, but...
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Sex-dependent association of serum vitamin D with muscle strength in older adults: NHANES 2001–2002
BackgroundAlthough several studies have suggested a potential positive association between serum vitamin D levels and muscle strength in older...
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A phase III randomized clinical trial comparing laparoscopic radical hysterectomy based on open state with abdominal radical hysterectomy in patients with early-stage cervical cancer
BackgroundCervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women, The standard...
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Enhancing Alcohol-Related Research in Africa: Possibility for a Continental-Wide Alliance
Alcohol-related harms constitute a major public health concern in Africa, with high rates of alcohol consumption and associated negative health and...
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Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report
BackgroundSurgery is the standard care for patients with early-stage lung cancer, and stereotactic body radiation therapy is an option for those who...
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Introduction of novel intravascular ultrasound preceding with angled guiding catheter (I-PAD) technique to treat chronic total occlusions in peripheral artery disease
BackgroundThe optimal endovascular treatment (EVT) for chronic total occlusion (CTO) lesions in patients with peripheral artery disease (PAD) has...
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A Persian validation of the burnout assessment tool
BackgroundBurnout is an increasing public health concern. Its prevalence has extended across diverse professions globally, posing significant...
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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing...
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Accuracy of second and third molar maturity indices, Olze, Haavikko, and Demirjian methods for 14- and 16-year-old age thresholds assessment in Croatian children and adolescents
This study explores the reliability of four established legal age threshold estimation approaches in a Croatian sample. We applied Haavikko stages,...
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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A double CYP27A1 gene mutation in spinal cerebrotendinous xanthomatosis in a patient presenting with spastic gait: a case report
BackgroundCerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene....
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Modified femtosecond laser-assisted arcuate keratotomy for managing low corneal astigmatism using trifocal intraocular lens implantation in Chinese cataract patients
To evaluate the visual outcome and astigmatic correction following trifocal intraocular lens (IOL) implantation using the modified femtosecond...
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Health and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study
BackgroundThe ongoing global crisis of Higher Education (HE) institutions during the post-COVID-19 pandemic period has increased the likelihood of...
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The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff
BackgroundSharing trial results with participants is a moral imperative, but too often does not happen in appropriate ways.
MethodsWe carried out...