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Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors
In some cancers mutant p53 promotes the occurrence, development, metastasis and drug resistance of tumours, with targeted protein degradation seen as...
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Role of p53/circRNA0085439/Ku70 axis in DNA damage response in lung cells exposed to ZnO nanoparticles: Involvement of epigenetic regulation
BackgroundNano-Zinc oxide (Nano-ZnO) has been increasingly applied in agriculture, industry and biomedicine. However, the genotoxic effects of...
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Real-time in situ observation of P53-mediated cascade activation of apoptotic pathways with nucleic acid multicolor fluorescent probes based on symmetrical gold nanostars
T-2 toxin, one of the most dangerous natural pollutants, induces apoptosis through multiple pathways. Amongst, P53 mediated apoptosis pathway, an...
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Biomembrane-grafted dendrimer-polymeric conjugates for targeting p53—a pioneer innovation in cancer nanomedicine
Cancer remains a significant global health challenge, demanding innovative approaches to enhance the effectiveness and precision of therapies. In...
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HDAC5-mediated exosomal Maspin and miR-151a-3p as biomarkers for enhancing radiation treatment sensitivity in hepatocellular carcinoma
BackgroundTumor-derived exosomes are critical elements of the cell–cell communication response to various stimuli. This study aims to reveal that the...
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Peptide L1H9 derived from the interaction of structural human rhomboid family 1 and 80-kDa subunit of Ku antigen sensitizes breast cancer to chemoradiotherapy
Chemoradio-resistance remains a major challenge in breast cancer (BC). Human rhomboid family 1 (RHBDF1) is known as an oncoprotein, but its function...
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Crocin-loaded zein beta-cyclodextrin nanoparticles: a promising strategy for inducing apoptosis in pancreatic cancer cells
Nanotechnology is a promising field for develo** drug delivery systems that can enhance therapeutic efficacy. In this study, we aimed to create...
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Delivery of letrozole-encapsulated niosomes via a 3D bioprinting gelatin–alginate scaffold for potential breast cancer treatment
3D printing technology is a powerful tool in scaffold engineering for biomedical applications, especially in anticancer activities and drug delivery....
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Multi-sensitive functionalized niosomal nanocarriers for controllable gene delivery in vitro and in vivo
MicroRNAs, which can contribute to numerous cellular functions through post-transcriptional silencing, have become well-documented candidates for...
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Evaluation of the cytotoxic effects of silver-zinc oxide nanoparticles synthesized by green method on sw480 cell line
In recent years, metal nanocomposites (NCs) have widely been studied due to their several applications in therapeutic activities. The current study...
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Development of highly efficient niosomal systems for co-delivery of drugs and genes to treat breast cancer in vitro and in vivo
In this paper, we step forward in optimizing the efficiency of niosomal systems for carrying curcumin and miR-34a as single-/co-delivery to treat...
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Novel pH responsive hesperidin nanoformulation exerts anticancer activity on lung adenocarcinoma cells by targeting Akt/mTOR and MEK/ERK pathways
Zinc oxide nanoparticle based drug delivery enhances bioavailability of anticancer drug to the tumor site. We developed novel biocompatible ZnO...
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The human immune cell simulated anti-breast cancer nanorobot: the efficient, traceable, and dirigible anticancer bio-bot
BackgroundVarious types of cancer therapy strategies have been investigated and successfully applied so far. There are a few modern strategies for...
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A multifunctional bioresponsive and fluorescent active nanogel composite for breast cancer therapy and bioimaging
Bio-responsive nanocomposites with facile fabrication and rational design are of great importance in the diagnosis and treatment of cancer. Herein,...
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Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: an in vitro study using hepatocellular carcinoma (HepG2)
The ongoing loss of human life owing to various forms of cancer necessitates the development of a more effective/honorable therapeutic approach....
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Harnessing rat derived model cells to assess the toxicity of TiO2 nanoparticles
Until now, a few studies have been conducted on the destructive effects of TiO 2 NPs in living organisms, and studies on the toxicity of TiO 2 NPs are...
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Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy
BackgroundCombinatorial systemic chemotherapy is a powerful treatment paradigm against cancer, but it is fraught with problems due to the emergence...
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Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways
BackgroundThe volatile fraction of frankincense ( Boswellia sacra ) oleogum was extracted, formulated in nanoemulsion and tested against lung cancer...
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Zinc oxide nanoparticles promote the aging process in a size-dependent manner
Zinc oxide (ZnO) nanoparticles (NPs) are generally utilized in cosmetic goods, sheds, biosensors, and delivery of drug. As in vitro ideal systems,...
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Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming
BackgroundTumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of cancer cell growth. This study is designed to combine the newly...
