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Application of mannose-modified fullerene immunomodulator selectively polarizes tumor-associated macrophages potentiating antitumor immunity
Polarization of tumor associated macrophages (TAMs) has been a promising therapeutic paradigm for tumor. However, how to achieve precise regulation...
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Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages
BackgroundBreast cancer is the neoplastic disease with the highest incidence and mortality in the female population worldwide. Treatment remains...
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Nanoparticles targeting tumor-associated macrophages: A novel anti-tumor therapy
The immunosuppressive tumor microenvironment (TME) is crucial in the occurrence of tumorigenesis, metastasis, and drug resistance. Among all stromal...
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Spatially targeting of tumor-associated macrophages and cancer cells for suppression of spontaneously metastatic tumor
The interaction between cancer cells and M2 tumor-associated macrophages (M2-TAMs) facilitates tumor growth and metastasis. However, cancer cells and...
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Identification of Detonation-Nanodiamond Particles and Detection of Their Localization in Human Macrophages and Mouse Lungs
AbstractNanodiamonds modified with functional groups are obtained for targeted drug delivery. A set of methods for identifying nanodiamonds in...
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MCP-1 and IL-4 encapsulated hydrogel particles with macrophages enrichment and polarization capabilities for systemic lupus erythematosus treatment
Macrophages play a pivotal role in systemic lupus erythematosus (SLE) therapy. Efforts have been made to develop multifunctional drug delivery...
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Protein nanoparticle cellular fate and responses in murine macrophages
Nanoparticles (NPs), both organic and inorganic, have been identified as tools for diagnostic and therapeutic (theranostic) applications. Macrophages...
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Collagen-derived peptide, DGEA, inhibits pro-inflammatory macrophages in biofunctional hydrogels
Macrophages are innate immune cells that play important roles in wound healing. Particularly, M1 macrophages are considered pro‐inflammatory and...
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Sequential activation of M1 and M2 phenotypes in macrophages by Mg degradation from Ti-Mg alloy for enhanced osteogenesis
BackgroundEven though the modulatory effects of Magnisum (Mg) and its alloys on bone-healing cells have been widely investigated during the last two...
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An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy. In this work, we demonstrate that an...
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Reprogramming tumor-immune cell communication with a radiosensitive nanoregulator for immunotherapy
Modulating tumor-associated macrophages from tumor-promoting M2 to tumoricidal M1 phenotype is promising for anti-tumor immunotherapy but remains...
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Engineering SIRPα cellular membrane-based nanovesicles for combination immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment for their unprecedented clinical efficacy. Signal regulatory protein α...
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RETRACTED ARTICLE: microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway
ObjectivesNasopharyngeal carcinoma (NPC) is a type of nasopharyngeal disease with high metastasis and invasion properties. Tumor-associated...
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Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma
BackgroundTumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is...
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Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fibroblasts
BackgroundImmunogenic cell death (ICD) induced by different cancer treatments has been widely evaluated to recruit immune cells and trigger the...
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Ultrasound-visualized nanocarriers with siRNA for targeted inhibition of M2-like TAM polarization to enhance photothermal therapy in NSCLC
Photothermal therapy (PTT) has received a lot of attention as a promising strategy for eliminating tumors quickly. However, the unavoidable...
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Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy
Many metal complexes not only had excellent cytotoxic antitumor effects but also could function as a positive immunomodulatory to improve antitumor...
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Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment
BackgroundAlthough programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy...
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Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer
Despite therapeutic advancements, the prognosis of locally advanced non-small cell lung cancer (LANSCLC), which has invaded multiple lobes or the...
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Reprogramming the tumor microenvironment with biotechnology
The tumor microenvironment (TME) is a unique environment that is developed by the tumor and controlled by tumor-induced interactions with host cells...
