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Principles of amino-acid–ribonucleotide interaction revealed by binding affinities between homogeneous oligopeptides and single-stranded RNA molecules
We have determined the binding strengths between ribonucleotides of adenine (A), guanine (G), uracil (U), and cytosine (C) in homogeneous...
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Isothermal self-assembly of multicomponent and evolutive DNA nanostructures
Thermal annealing is usually needed to direct the assembly of multiple complementary DNA strands into desired entities. We show that, with a...
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Single-molecule analysis of DNA base-stacking energetics using patterned DNA nanostructures
The DNA double helix structure is stabilized by base-pairing and base-stacking interactions. However, a comprehensive understanding of dinucleotide...
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Multi-micron crisscross structures grown from DNA-origami slats
Living systems achieve robust self-assembly across a wide range of length scales. In the synthetic realm, nanofabrication strategies such as DNA...
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Magnetically controlled anisotropic light emission of DNA-functionalized supraparticles
AbstractIn this article, we show the DNA-functionalization of supraparticles, form their network, and manipulate the optical features of these...
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Programming nanoparticle valence bonds with single-stranded DNA encoders
Nature has evolved strategies to encode information within a single biopolymer to program biomolecular interactions with characteristic...
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Solid-State Nanopore Sensing Enhanced by Designed DNA Nanostructures
Solid-state nanopores are versatile single-molecule tools for label-free detection of biomolecules including DNA, RNA and protein by passing these...
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Colloidal quasicrystals engineered with DNA
In principle, designing and synthesizing almost any class of colloidal crystal is possible. Nonetheless, the deliberate and rational formation of...
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Towards the development of an electrochemical random access DNA memory (e-RADM)
As a result of the exponentially growing amount of information being produced, new data storage solutions are required. DNA has attracted significant...
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An intelligent DNA nanodevice for precision thrombolysis
Thrombosis is a leading global cause of death, in part due to the low efficacy of thrombolytic therapy. Here, we describe a method for precise...
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DNA-origami-directed virus capsid polymorphism
Viral capsids can adopt various geometries, most iconically characterized by icosahedral or helical symmetries. Importantly, precise control over the...
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Prediction of DNA origami shape using graph neural network
Unlike proteins, which have a wealth of validated structural data, experimentally or computationally validated DNA origami datasets are limited. Here...
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Bio-inspired Functional DNA Architectures
DNA has become an attractive construction template for a wide range of self-assembled systems, ranging from modified functional duplexes to elaborate...
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A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower
Molecular engineering seeks to create functional entities for modular use in the bottom-up design of nanoassemblies that can perform complex tasks....
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Hierarchical assembly of DNA origami nanostructures
The use of DNA nanotechnology is rapidly growing due to the unprecedented programmability of geometric, mechanical, and dynamic properties. This...
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Functional Molecule-Templated DNA Molecular Architectonics
The fascinating molecular recognition and structural properties make DNA an ideal building block to construct predictable molecular and...
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Fast and compact DNA logic circuits based on single-stranded gates using strand-displacing polymerase
DNA is a reliable biomolecule with which to build molecular computation systems. In particular, DNA logic circuits (diffusion-based) have shown good...
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A DNA turbine powered by a transmembrane potential across a nanopore
Rotary motors play key roles in energy transduction, from macroscale windmills to nanoscale turbines such as ATP synthase in cells. Despite our...
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Site-directed placement of three-dimensional DNA origami
The combination of lithographic methods with two-dimensional DNA origami self-assembly has led, among others, to the development of photonic crystal...
