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Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion
The enhanced permeability and retention (EPR) effect alone is not enough for nanoparticles to reach the target. Combination of active and passive...
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Mesothelin-targeted MRI for assessing migration, invasion, and prognosis in malignant pleural mesothelioma
BackgroundMesothelin (MSLN) has been implicated in cancer migration, invasion, and prognosis, making it a potential tumor marker. However, the...
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Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function...
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Engineering CAR-expressing natural killer cells with cytokine signaling and synthetic switch for an off-the-shelf cell-based cancer immunotherapy
Immune cells can be genetically engineered with a synthetic chimeric antigen receptor (CAR) to eliminate cancer cells, but clinical efficacy in solid...
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Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2
Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every year. Chemotherapy is the primary therapeutic...
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Tumor-derived systems as novel biomedical tools—turning the enemy into an ally
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases...
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Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Immunotherapy has reached clinical success in the last decade, with the emergence of new and effective treatments such as checkpoint blockade therapy...
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CAR-T Cells: Next Generation Cancer Therapeutics
Chimeric antigen receptors (CAR) are synthetic receptors consisting of recognition domains derived from antibodies coupled to the signaling domains...
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Design, Fabrication, and Modification Protocols of Functional Micro-/Nanoimaging Probes
The biosafety of micro-/nanoimaging probes is one of the most important elements that should be taken into consideration before their design and...
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Evaluating Carcinogenic Potential of Carbon Nanomaterials
The goal is to review the adverse health effects, in particular carcinogenic effects, of various carbon-based nanomaterials during their life cycle,...
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Nanotechnologies for enhancing cancer immunotherapy
Immunotherapy, a burgeoning field differs from traditional cancer treatments, is revolutionizing oncologic therapeutics. It aims to stimulate the...
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MRI and Ultrasound Imaging of Nanoparticles for Medical Diagnosis
Magnetic resonance imaging (MRI) and ultrasound (US) are two prominent medical imaging modalities. They are extensively and routinely used in various...
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Development of mRNA vaccines and their prophylactic and therapeutic applications
Nucleic acid vaccines have attracted enormous attention for resolving the limitations of conventional vaccines using live attenuated viruses. Because...
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Silicon Quantum Dots: From Synthesis to Bioapplications
Silicon quantum dots (Si QDs) represent a special class of nanomaterials with distinctive properties, being used in different applications such as...
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Quantum dots: synthesis, bioapplications, and toxicity
This review introduces quantum dots (QDs) and explores their properties, synthesis, applications, delivery systems in biology, and their toxicity....
