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Membrane-anchored DNA nanojunctions enable closer antigen-presenting cell–T-cell contact in elevated T-cell receptor triggering
How the engagement of a T-cell receptor to antigenic peptide-loaded major histocompatibility complex on antigen-presenting cells (APCs) initiates...
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Programmable multispecific DNA-origami-based T-cell engagers
Multispecific antibodies have emerged as versatile therapeutic agents, and therefore, approaches to optimize and streamline their design and assembly...
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Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food and Drug Administration, has shown curative potential in patients...
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Cleavable, Covalently Linked, Affinity Coupling Immune Magnetic Nanoparticles for Specifically Depleting T Cells
Hematopoietic stem cell (HSC) transplantation has become an accepted therapeutic modality for patients with hematopoietic disorders. However,...
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Zinc-Doped Gold/Cobalt Ferrite Nanoparticles in Studying the Cytotoxic Effect on T-Lymphoblastic Leukemia Cells
The rapid development of the nanomaterials’ application’s fields in biomedicine is associated with the expanded possibilities of combining their...
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Impact of TiO2 nanomaterials with different morphologies and their calcium phosphate composites on hemostasis and immunocompatibility
The increasing use of TiO 2 nanomaterials (TiNMs) in bone tissue engineering raises concerns about their biocompatibility. To date, majority of...
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Photothermal nanofibres enable safe engineering of therapeutic cells
Nanoparticle-sensitized photoporation is an upcoming approach for the intracellular delivery of biologics, combining high efficiency and throughput...
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A Dual-Band Terahertz Metamaterial Absorber Using an All-Metal Aluminum Hexagonal Metasurface Structure for Sensing of Cancerous Cells
This article proposes a dual-band terahertz metamaterial absorber (TMA) where all components of the designed structure are made of aluminum (optical)...
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A DNA origami device spatially controls CD95 signalling to induce immune tolerance in rheumatoid arthritis
DNA origami is capable of spatially organizing molecules into sophisticated geometric patterns with nanometric precision. Here we describe a...
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Bi-metallic, ferric oxide, and carbon nanotube-assisted SPR sensor for cancer detection
In biomedical diagnostics, surface plasmon resonance (SPR) sensors have emerged as one of the most valuable instruments, particularly for identifying...
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Cellular binding, uptake and biotransformation of silver nanoparticles in human T lymphocytes
Our knowledge of uptake, toxicity and detoxification mechanisms as related to nanoparticles’ (NPs’) characteristics remains incomplete. Here we...
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Carbon Nanotropes: Potential Nanomaterials for Drug Delivery and Biomedical Applications
Carbon nanotropes, fullerene, carbon nanotubes, and graphene have gained extensive attention due to their robust nature, ultrathin structure, high...
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Improvement of hemocompatibility of γ-Fe2O3 nanoparticles via their covering with complex poly(N,N-dimethylacrylamide) and SiO2 shell
The biocompatibility of NPs to blood cells is a key issue when these NPs are planned for intravenous application because of potential contact with...
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Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer
Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows...
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Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Immunotherapy has reached clinical success in the last decade, with the emergence of new and effective treatments such as checkpoint blockade therapy...
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The Contribution of Stabilizer to Silver Nanoparticle Cytotoxicity in Experiments on Endothelial and Fibroblast-Like Cells
AbstractThe contributions of stabilizer monomers and micelles to the toxic effect of aqueous solutions of nanoparticles were determined in studies of...
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Evidence for biological effects in the radiosensitization of leukemia cell lines by PEGylated gold nanoparticles
Gold nanoparticles (Au NPs) are promising radiosensitizers for cancer therapy. While the radiosensitizing effects of Au NPs have been shown in many...
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Three-dimensional localization microscopy in live flowing cells
Capturing the dynamics of live cell populations with nanoscale resolution poses a significant challenge, primarily owing to the speed-resolution...
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Polymeric biomaterial-inspired cell surface modulation for the development of novel anticancer therapeutics
Immune cell-based therapies are a rapidly emerging class of new medicines that directly treat and prevent targeted cancer. However multiple...
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Regulation effect of osteoblasts towards osteocytes by silk fibroin encapsulation
Herein, the rational design micromilieus involved silk fibroin (SF)-based materials have been used to encapsulate the osteoblasts, forming an...