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Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy
Dual inhibition of glycolysis and oxidative phosphorylation (OXPHOS) can break the metabolic plasticity of cancer cells to inhibit most energy supply...
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Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation
BackgroundMost ovarian cancers are diagnosed at advanced stages characterized by abdominal dissemination and frequently exhibit chemoresistance....
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Nanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer
BackgroundNanocarrier delivery of small interfering RNAs (siRNAs) to silence cancer-associated genes is a promising method for cancer treatment....
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A biodegradable nanodrug with highly efficient treatment effect by remodeling tumor microenvironment and manipulating energy metabolism against colorectal cancer
Cisplatin (CDDP), a widely used chemotherapy drug for colorectal cancer, suffers from rapid clearance, resistance, and nonspecific delivery....
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Nutrient-delivery and metabolism reactivation therapy for melanoma
To fulfil the demands of rapid proliferation, tumour cells undergo significant metabolic alterations. Suppression of hyperactivated metabolism has...
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Recycling Technologies for Polyurethane Wastes (A Survey)
The world production of polyurethanes (PU) currently exceeds 18 mln. tons. Moreover, it is expected that, by 2024, it will become greater than 24...
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Nanosystem-mediated lactate modulation in the tumor micro environment for enhanced cancer therapy
Metabolic reprogramming allows tumor cells to prefer aerobic glycolysis as the main energy source, resulting in the massive accumulation of lactate...
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Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy
Mitochondrial bioenergy plays a vital role in the occurrence and development of cancer. Although strategies to impede mitochondrial energy supply...
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Synergic effect of cellulose- and carbon-based nanostructure derived from agricultural biowaste on the performance of polyester–HDPE nanocomposite
This work was done to develop cellulose nanostructures (CNSs) and carbon nanostructures as effective materials for valorization of agro and plastic...
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RETRACTED ARTICLE: Synthesis, molecular docking and molecular dynamics simulation of 1,4-bis(4,5-diphenyl-1H-imidazol-2-yl) benzene as a potential inhibitor against LDHA
Lactate dehydrogenase is one of the major enzymes for the anaerobic metabolic pathway. It belongs to the oxidoreductases class and is responsible for...
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Synthesis of PET-based urethane-modified alkyd resins from depolymerization intermediates of post-consumer PET bottles: coating properties and thermal behaviors
AbstractUrethane-modified alkyd resins were synthesized using the depolymerization intermediates obtained from simultaneous hydrolysis–glycolysis...
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Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming
BackgroundTumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of cancer cell growth. This study is designed to combine the newly...
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Evaluation of the Effect of the Application of Electrical Current in Micromamperage During Alcoholic Fermentation by Saccharomyces Cerevisiae
Bioethanol is a compound traditionally produced from the fermentation of specific sugars. Different substrates can also be used for this purpose...
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Plastic as Fuel of the Future
A range of technologies have been developed to obtain energy and materials from plastics. This has been focused on nonbiodegradable fossil-derived...
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Polymer Recycling Techniques
This chapter includes an introduction to polymers and their recycling methods. Recycling is the most suitable alternative to control and avoid the...
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Recycling in Textiles
This chapter briefly presents the need of recycling of textiles and why there is so much emphasis globally to recycle the textiles. The recycling...
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Novel robust upcycling approach for the manufacture of value-added polymers based on mixed (poly)urethane scraps
Plastic pollution undoubtedly is a big global issue for present and future generations. Despite numerous activities in the field, the recycling of...
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Bioenergetics
The field of bioenergetics deals with diverse types of energy transformation in cells; in particular, the reactions involving adenosine triphosphate...
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Polymer Recycling by Radiation
Polymers have become integral part of human lives all over the world, owing to their multi-purpose utility starting from daily household commodities...
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Composites Based on Polymeric Matrices Recycled from Different Wastes and Natural Fibers
The main advances developed during the last years on the preparation and characterization of composites based on recycled thermoplastics and natural...