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In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity
Chimeric antigen receptor T (CAR T) cell immunotherapy is successful at treating many cancers. However, it often induces life-threatening cytokine...
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Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food and Drug Administration, has shown curative potential in patients...
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Cell-Based Vaccines: Frontiers in Medical Technology for Cancer Treatment
PurposeCancer is now regarded as one of the significant public health concerns, and it is predicted to overtake cardiovascular diseases in 2060....
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Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Immunotherapy has reached clinical success in the last decade, with the emergence of new and effective treatments such as checkpoint blockade therapy...
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DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation
Biomaterials can improve the safety and presentation of therapeutic agents for effective immunotherapy, and a high level of control over surface...
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Effects of Damage Mode on Crack Propagation Pattern in Additively Manufactured Honeycomb Cellular Panel
Planar cellular structure panels are affected by a series of factors, which can produce various types of initial damage within the structure and thus...
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CAR-T Cells: Next Generation Cancer Therapeutics
Chimeric antigen receptors (CAR) are synthetic receptors consisting of recognition domains derived from antibodies coupled to the signaling domains...
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The Challenge of Variability in Chimeric Antigen Receptor T Cell Manufacturing
AbstractAutologous chimeric antigen receptor (CAR) T cell manufacturing involves the modification and expansion of T cells obtained by apheresis...
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Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function...
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Bioengineering of nano metal-organic frameworks for cancer immunotherapy
Immunotherapy techniques, such as immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell therapies and cancer vaccines, have been...
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M2-type macrophage membrane-mediated delivery of Carvedilol nanocomplex for acute liver failure treatment and remodeling inflammatory microenvironment
Interactions of hepatic macrophages with local inflammatory microenvironment is the key factor promoting the development of acute liver failure...
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Responsive biomaterials: optimizing control of cancer immunotherapy
Immunotherapy has emerged as an eminent and effective modality in the treatment of cancer. However, current cancer immunotherapies lack spatial and...
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Immunoengineering can overcome the glycocalyx armour of cancer cells
Cancer cell glycocalyx is a major line of defence against immune surveillance. However, how specific physical properties of the glycocalyx are...
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Ni–Fe alloy soft magnetic protective coating of new energy vehicles and the internal electromagnetic radiation characteristics
With the development of intelligent, unmanned and connected cars, the electromagnetic environment inside the car is becoming more and more complex....
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Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours
Adoptive T-cell therapy against solid tumours is limited by the apoptosis resistance mechanisms of tumour cells and by the extracellular,...
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Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
Cancer immunotherapy, which harnesses the power of the immune system, has shown immense promise in the fight against malignancies. Messenger RNA...
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Synthesis and characterization of silver nanoparticles loaded with carboplatin as a potential antimicrobial and cancer therapy
In recent studies with silver nanoparticles, it has been reported that the use of nanoparticles in carrier drug systems increases tumor suppression...
