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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune...
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The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection
Mitochondria react to infection with sub-lethal signals in the apoptosis pathway. Mitochondrial signals can be inflammatory but mechanisms are only...
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The consequences of viral infection on protists
Protists encompass a vast widely distributed group of organisms, surpassing the diversity observed in metazoans. Their diverse ecological niches and...
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Hypermethylated genome of a fish vertebrate iridovirus ISKNV plays important roles in viral infection
Iridoviruses are nucleocytoplasmic large dsDNA viruses that infect invertebrates and ectothermic vertebrates. The hypermethylated genome of...
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ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms remain poorly understood....
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Viral Infection Induces Changes to the Metabolome, Immune Response and Development of a Generalist Insect Herbivore
Host plant consumption and pathogen infection commonly influence insect traits related to development and immunity, which are ultimately reflected in...
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Serine-arginine protein kinases and their targets in viral infection and their inhibition
Accumulating evidence has consolidated the interaction between viral infection and host alternative splicing. Serine-arginine (SR) proteins are a...
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Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids
Herpes simplex encephalitis is a life-threatening disease of the central nervous system caused by herpes simplex viruses (HSVs). Following standard...
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Immunomodulatory Effects of Vitamin D and Zinc on Viral Infection
Several nutrients are crucial in enhancing the immune system and preserving the structural integrity of bodily tissue barriers. Vitamin D (VD) and...
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The VP53 protein encoded by RNA2 of a fabavirus, broad bean wilt virus 2, is essential for viral systemic infection
Plant viruses evolves diverse strategies to overcome the limitations of their genomic capacity and express multiple proteins, despite the constraints...
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Decoding epitranscriptomic regulation of viral infection: map** of RNA N6-methyladenosine by advanced sequencing technologies
Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic...
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Combined Host-Pathogen Fate Map** to Investigate Lung Macrophages in Viral Infection
Macrophage identity, as defined by epigenetic, transcriptional, proteomic, and functional programs, is greatly impacted by cues originating from the...
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Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
BackgroundViral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing...
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The Possible Mechanisms of Cu and Zn in the Treatment and Prevention of HIV and COVID-19 Viral Infection
Due to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many...
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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis
Memory CD8 + T cells play a crucial role in infection and cancer and mount rapid responses to repeat antigen exposure. Although memory cell...
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Viral transmission and infection prevalence in a cannibalistic host–pathogen system
Cannibalism, while prevalent in the natural world, is often viewed as detrimental to a cannibal’s health, especially when they consume...
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N6-methyladenosine modification—a key player in viral infection
N 6 -methyladenosine (m 6 A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is...
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Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis
The microbiota-associated factors that influence host susceptibility and immunity to enteric viral infections remain poorly defined. We identified...
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An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
Viruses communicate with their hosts through interactions with proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often...
