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Ribosomal proteins: the missing piece in the inflammation puzzle?
Ribosomal proteins (RPs) are constituents of macromolecular machinery, ribosome that translates genetic information into proteins. Besides ribosomal...
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Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates
Ribosome biogenesis is among the most resource-intensive cellular processes, with ribosomal proteins accounting for up to half of all newly...
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Label-Free Quantitation of Ribosomal Proteins from Bacillus subtilis for Antibiotic Research
Current research is focusing on ribosome heterogeneityRibosome heterogeneity as a response to changing environmental conditions and stressesStresses....
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Identification of genes related to ribosomal proteins in colorectal cancer: exploring their potential as biomarkers, prognostic indicators, and therapeutic targets
BackgroundColorectal cancer (CRC) ranks as the third most commonly diagnosed cancer in both females and males, underscoring the need for the...
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Ribosomal Profiling by Gradient Fractionation of Cell Lysates
Ribosomal profiling is a widely used technique for deep sequencing of ribosome-protected mRNA and for measuring ribosome status in cells. It is a...
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A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation
During transcription of eukaryotic ribosomal DNA in the nucleolus, assembly checkpoints exist that guarantee the formation of stable precursors of...
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Costs of ribosomal RNA stabilization affect ribosome composition at maximum growth rate
Ribosomes are key to cellular self-fabrication and limit growth rate. While most enzymes are proteins, ribosomes consist of 1/3 protein and 2/3...
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WLP3 Encodes the Ribosomal Protein L18 and Regulates Chloroplast Development in Rice
Plastid ribosomal proteins play a crucial role in the growth and development of plants, mainly in the gene expression and translation of key genes in...
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Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner
To investigate the mechanism(s) underlying the expression of primate-specific microRNAs (miRs), we sought DNA regulatory elements and proteins...
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and...
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Phage proteins target and co-opt host ribosomes immediately upon infection
Bacteriophages must seize control of the host gene expression machinery to replicate. To bypass bacterial anti-phage defence systems, this host...
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Chemo-Enzymatic Synthesis of Non-ribosomal Macrolactams by a Penicillin-Binding Protein-Type Thioesterase
Penicillin-binding protein-type thioesterases (PBP-type TEs) are an emerging family of non-ribosomal peptide cyclases. PBP-type TEs exhibit distinct...
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KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion
Ribosome assembly is orchestrated by many assembly factors, including ribosomal RNA methyltransferases, whose precise role is poorly understood....
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Ribosomal profiling of human endogenous retroviruses in healthy tissues
Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the...
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Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs
Selective translation allows to orchestrate the expression of specific proteins in response to different signals through the concerted action of...
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Increasing the number of ribosomal uL6 mRNA copies accelerates aging of the budding yeast
BackgroundAging is a biological process from which there is no escape. Diverse factors contribute to aging, most notably cell energy metabolism....
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Advances in the adenylation domain: discovery of diverse non-ribosomal peptides
AbstractNon-ribosomal peptide synthetases are mega-enzyme assembly lines that synthesize many clinically useful compounds. As a gatekeeper, they have...
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Molecular Biology of Non-ribosomal Peptide (NRP) and Polyketide (PK) Biosynthesis in Cyanobacteria
Secondary metabolites produced by cyanobacteria are numerous and structurally diverse, with a focus on non-ribosomal peptide and polyketide...
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PRFect: a tool to predict programmed ribosomal frameshifts in prokaryotic and viral genomes
BackgroundOne of the stranger phenomena that can occur during gene translation is where, as a ribosome reads along the mRNA, various cellular and...
