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Artificial Intelligence and Radiotherapy: Impact on Radiotherapy Workflow and Clinical Example
Radiation oncology is a discipline in which a treatment is delivered to the tumor using three main modalities: external beam radiotherapy (ERT),...
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Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy
Tumor cells establish a robust self-defense system characterized by hypoxia, antioxidant overexpression, DNA damage repair, and so forth to resist...
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Harnessing progress in radiotherapy for global cancer control
The pace of technological innovation over the past three decades has transformed the field of radiotherapy into one of the most technologically...
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The SGLT2 inhibitor canagliflozin suppresses growth and enhances prostate cancer response to radiotherapy
Radiotherapy is a non-invasive standard treatment for prostate cancer (PC). However, PC develops radio-resistance, highlighting a need for agents to...
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The emerging role of exosomes in radiotherapy
Presently, more than half of cancer patients receive radiotherapy to cure localized cancer, palliate symptoms, or control the progression of cancer....
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MicroRNA: Role in Gene Regulation, Disease Prognosis, Radiotherapy, and the Activity of Radioprotectors
AbstractMicroRNAs are small, highly conserved noncoding RNAs (containing about 20 nucleotides), involved in the regulation of gene activity on the...
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Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity
Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has...
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Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy
Pyroptotic cell death, an inflammatory form of programmed cell death (PCD), is emerging as a potential therapeutic opportunity for radiotherapy (RT)....
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Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths
The advancement of novel technologies, coupled with bioinformatics, has led to the discovery of additional genes, such as long noncoding RNAs...
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Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
BackgroundThe primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingly recognized the...
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The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy
Hypoxia is frequently found in solid tumors and is known to increase the resistance to several kinds of treatment modalities including radiation...
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Alterations in hypothalamic-pituitary axis (HPA) hormones 6 months after cranial radiotherapy in adult patients with primary brain tumors outside the HPA region
BackgroundCranial radiotherapy is a common treatment for brain tumors, but it can affect the hypothalamic-pituitary (H-P) axis and lead to hormonal...
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HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy
Radiotherapy resistance is a major obstacle to nasopharyngeal carcinoma (NPC) therapy and contributes to tumour recurrence and metastasis. Lipid...
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Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade...
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Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics
Multimodal nanoparticles, utilizing quantum dots (QDs), mesoporous silica nanoparticles (MSNs), and gold nanoparticles (Au NPs), offer substantial...
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Transposable elements potentiate radiotherapy-induced cellular immune reactions via RIG-I-mediated virus-sensing pathways
Radiotherapy (RT) plus immunotherapy is a promising modality; however, the therapeutic effects are insufficient, and the molecular mechanism requires...
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SIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer
High-dose hypofractionated radiotherapy (HRT) is an important anticancer treatment modality that activates antitumor host immune responses. However,...
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New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy
Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal cancer patients often results in individuals...
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Exon Sequence Analysis of the ATG5, ATG12, ATG9B Genes in Colorectal Cancer Patients During Radiotherapy
Radiotherapy (RT) which is a treatment regime for cancer patients may cause genetic instability and side effects. Etiological associations exist...
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Speeding up Simulations for Radiotherapy Research by Means of Machine Learning
Radiotherapy is one of the most widely used treatments for cancer by irradiating the tumor volume. However, one of its disadvantages is that healthy...