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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded...
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Microtubule polarity determines the lineage of embryonic neural precursor in zebrafish spinal cord
The phenomenal diversity of neuronal types in the central nervous system is achieved in part by the asymmetric division of neural precursors. In...
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CD83 expression characterizes precursor exhausted T cell population
T cell exhaustion is a main obstacle against effective cancer immunotherapy. Exhausted T cells include a subpopulation that maintains proliferative...
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Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate
AbstractGlycosidic osmolytes are widespread natural compounds that protect microorganisms and their macromolecules from the deleterious effects of...
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Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration
Chemogenetic approaches employing ligand-gated ion channels are advantageous regarding manipulation of target neuronal population functions...
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Generalized precursor prediction boosts identification rates and accuracy in mass spectrometry based proteomics
Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers....
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SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
BackgroundTransposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements...
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Integration of phenylalanine precursor feeding and elicitor treatment in concert with the cellulase-assisted extraction approach to improve stilbene compound production
Trans -resveratrol, trans -arachidin-1 (Ara-1), and trans -arachidin-3 (Ara-3) are major stilbene compounds found in elicited peanut hairy root culture...
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Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10–13
A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin ( 1 ), was isolated from culture broth of actinomycete Kitasatospora...
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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
In Mycobacterium tuberculosis , Rv3806c is a membrane-bound phosphoribosyltransferase (PRTase) involved in cell wall precursor production. It...
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Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism
Antimicrobial resistance is a leading cause of mortality, calling for the development of new antibiotics. The fungal antibiotic plectasin is a...
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Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
BackgroundThe maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate...
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CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
BackgroundThe CRX -associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. However, based on...
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Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid
Tripropeptin C, a non-ribosomal cyclic lipopeptide containing three proline residues, exhibits excellent efficacy in the mouse-methicillin-resistant St...
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Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein
BackgroundNucleobindin-2 (Nucb2) is a multidomain protein that, due to its structure, participates in many physiological processes. It was originally...
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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins...
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Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway
Osteoplastic precursors are critical for fracture repair and bone homeostasis maintenance. Cerium oxide nanoparticles (CeO 2 NPs) can promote the...
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The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid...
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Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation
Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2 , leads...
