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p53 and Ferroptosis
Ferroptosis is a form of oxidative cell death that relies on intracellular iron accumulation and lipid peroxidation. Recent studies have shown that...
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Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
The cavity-creating p53 cancer mutation Y220C is an ideal paradigm for develo** small-molecule drugs based on protein stabilization. Here, we have...
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Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts
The p53 tumor suppressor, encoded by the TP53 gene, serves as a major barrier against malignant transformation. Patients with Li-Fraumeni syndrome...
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Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues
Detecting and targeting precancerous cells in noncancerous tissues is a major challenge for cancer prevention. Massive stabilization of mutant p53...
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Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that provide structural support to the nucleus and contribute to...
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Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination
Tumor suppressor p53 prevents tumorigenesis by promoting cell cycle arrest and apoptosis through transcriptional regulation. Dysfunction of p53...
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Targeting tumor suppressor p53 for organ fibrosis therapy
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in...
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Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?
Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the tumor suppressor protein p53. Genetically modified...
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KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner
Breast cancer is the most common cancer affecting women worldwide. Many genes are involved in the development of breast cancer, including the Kruppel...
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Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis
Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid...
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Determinants of p53 DNA binding, gene regulation, and cell fate decisions
The extent to which transcription factors read and respond to specific information content within short DNA sequences remains an important question...
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SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability
SCML2 has been found to be highly expressed in various tumors. However, the extent to which SCML2 is involved in tumorigenesis and cancer therapy is...
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Emerging role and therapeutic implications of p53 in intervertebral disc degeneration
Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a huge economic burden on both individuals and society. With the...
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Complementary omics strategies to dissect p53 signaling networks under nutrient stress
Signaling trough p53is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human...
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Tissue specificity and spatio-temporal dynamics of the p53 transcriptional program
Transcription factors regulate hundreds of genes and p53 is no exception. As a stress responsive protein, p53 transactivates an array of downstream...
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p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
Lysosomes are single-membraned organelles that mediate the intracellular degradation of macromolecules. Various stress can induce lysosomal membrane...
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Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
Aneuploidy—the karyotype state in which the number of chromosomes deviates from a multiple of the haploid chromosome set—is common in cancer, where...
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The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy
The oncoprotein SET is frequently overexpressed in many types of tumors and contributes to malignant initiation and progression through multiple...
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Cuproptosis: p53-regulated metabolic cell death?
Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that utilize oxidative phosphorylation as the main metabolic...
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Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1
BackgroundThe cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type...
