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1. Regulatory landscape enrichment analysis (RLEA): a computational toolkit for non-coding variant enrichment and cell type prioritization

   Background

   As genomic studies continue to implicate non-coding sequences in disease, testing the roles of these variants requires insights into the...

   Samuel Rosean, Eric A. Sosa, ... John M. Greally in BMC Bioinformatics

   Article Open access 07 May 2024
   

2. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes

   Recent large-scale genomic association studies found evidence for a genetic link between increased risk of type 2 diabetes and decreased risk for...

   Viktoria Glunk, Samantha Laber, ... Melina Claussnitzer in Nature Metabolism

   Article 30 May 2023
   

3. SNP markers found in non-coding regions can distinguish among low-variant genotypes of Arabica and other coffee species

   Development of efficient and scalable methods for molecular identification of Coffea spp. are necessary to accelerate studies related to the...

   Alejandro Bolívar-González, Ramón Molina-Bravo, ... Andrés Gatica-Arias in Genetic Resources and Crop Evolution

   Article 10 December 2022
   

4. Methods for Functional Characterization of Genetic Polymorphisms of Non-Coding Regulatory Regions of the Human Genome

   Abstract

   Currently, numerous associations between genetic polymorphisms and various diseases have been characterized through the Genome-Wide...

   Aksinya N. Uvarova, Elena A. Tkachenko, ... Dmitry V. Kuprash in Biochemistry (Moscow)

   Article Open access 01 June 2024
   

5. Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements

   Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", but rather comprise critical elements...

   Sandra Iñiguez-Muñoz, Pere Llinàs-Arias, ... Diego M. Marzese in Cellular and Molecular Life Sciences

   Article Open access 20 June 2024
   

6. Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs

   Despite their fundamental role in assessing (patho)physiological cell states, conventional gene reporters can follow gene expression but leave scars...

   Dong-Jiunn Jeffery Truong, Niklas Armbrust, ... Gil Gregor Westmeyer in Nature Cell Biology

   Article Open access 07 November 2022
   

7. Predicted roles of long non-coding RNAs in abiotic stress tolerance responses of plants

   The plant genome exhibits a significant amount of transcriptional activity, with most of the resulting transcripts lacking protein-coding potential....

   IUH Imaduwage, Madhavi Hewadikaram in Molecular Horticulture

   Article Open access 15 May 2024
   

8. Transcription regulation by long non-coding RNAs: mechanisms and disease relevance

   Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions remain largely unknown. In this Review, we discuss the...

   Jorge Ferrer, Nadya Dimitrova in Nature Reviews Molecular Cell Biology

   Article 19 January 2024
   

9. Interrelated grid of non-coding RNA: An important aspect in Rheumatoid Arthritis pathogenesis

   Inflammation and autoimmunity are the root cause of rheumatoid arthritis, a destructive disease of joints. Multiple biomolecules are involved in the...

   Mohd Saquib, Prachi Agnihotri, ... Sagarika Biswas in Molecular Biology Reports

   Article 09 June 2023
   

10. Targeting non-coding RNA family members with artificial endonuclease XNAzymes

    Non-coding RNAs (ncRNAs) offer a wealth of therapeutic targets for a range of diseases. However, secondary structures and high similarity within...

    Maria J. Donde, Adam M. Rochussen, ... Alexander I. Taylor in Communications Biology

    Article Open access 24 September 2022
    

11. Editing and modification in trypanosomatids: the resha** of non-coding RNAs

    Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these...

    Mary Anne T. Rubio, Juan D. Alfonzo in Fine-Tuning of RNA Functions by Modification and Editing

    Chapter
    

12. Long non-coding RNAs: definitions, functions, challenges and recommendations

    Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA...

    John S. Mattick, Paulo P. Amaral, ... Mian Wu in Nature Reviews Molecular Cell Biology

    Article 03 January 2023
    

13. Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer

    Hormone receptor (HR)-positive breast cancer can become aggressive after develo** hormone-treatment resistance. This study elucidated the role of...

    Jeeyeon Lee, Eun-Ae Kim, ... ** Hyang Jung in BMC Molecular and Cell Biology

    Article Open access 22 April 2024
    

14. Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers

    Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for cancer diagnosis and treatment....

    Maryam Farzaneh, Mahrokh Abouali Gale Dari, ... Shirin Azizidoost in Journal of Cell Communication and Signaling

    Article Open access 13 June 2023
    

15. Roles of non-coding RNAs in the metabolism and pathogenesis of bladder cancer

    Bladder cancer (BC) is featured as the second most common malignancy of the urinary tract worldwide with few treatments leading to high incidence and...

    Daniel Ruben Akiola Sanya, Djamila Onésime in Human Cell

    Article 20 May 2023
    

16. Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division

    The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and long non-coding RNAs) in cell...

    Yuri Prozzillo, Maria Virginia Santopietro, ... Patrizio Dimitri in Cellular and Molecular Life Sciences

    Article Open access 20 November 2023
    

17. Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

    Human diseases have been a critical threat from the beginning of human history. Knowing the origin, course of action and treatment of any disease...

    Tamizhini Loganathan, George Priya Doss C in Functional & Integrative Genomics

    Article 10 January 2023
    

18. Role of long non-coding RNAs in the pathophysiology of Alzheimer’s disease and other dementias

    Dementia is the term used to describe a group of cognitive disorders characterized by a decline in memory, thinking, and reasoning abilities that...

    Lívia Cristina Ribeiro Teixeira, Izabela Mamede, ... Karina Braga Gomes in Molecular Biology Reports

    Article 01 February 2024
    

19. The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis

    Centromeres are established by nucleosomes containing the histone H3 variant CENP-A. CENP-A is recruited to centromeres by the Mis18–HJURP machinery....

    Hayato Hirai, Yuki Shogaki, Masamitsu Sato in Communications Biology

    Article Open access 15 August 2022
    

20. Deciphering the Role of Exosomal Non-Coding RNA (ncRNA) in Drug Resistance of Gastrointestinal Tumors; an Updated Review

    One of the most prevalent types of cancer worldwide today is gastric intestinal (GI) tumors. To guarantee their lives, people with a developed GI...

    Nafiseh Tashakori, Maryam Armanfar, ... Fatemeh Abedini in Cell Biochemistry and Biophysics

    Article 15 June 2024