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N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alzheimer’s or Parkinson’s, as well...
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Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway
Chronic stress significantly elevates the expression levels of various neurotransmitters in the tumour microenvironment, thereby promoting the cell...
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Assessment of Purity, Functionality, Stability, and Lipid Composition of Cyclofos-nAChR-Detergent Complexes from Torpedo californica Using Lipid Matrix and Macroscopic Electrophysiology
The main objective of the present study was to find detergents that can maintain the functionality and stability of the Torpedo californica nicotinic...
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nAChR-PEP-PRED: A Robust Tool for Predicting Peptide Inhibitors of Acetylcholine Receptors Using the Random Forest Classifier
Nicotinic acetylcholine receptors (nAChR) are interesting therapeutic targets due to their involvement in the development of different types of...
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The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion
α 5 nicotinic acetylcholine receptor ( α 5-nAChR) is associated with the progression of smoking-related lung adenocarcinoma (LUAD), but the molecular...
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State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor
The ability of the Torpedo nicotinic acetylcholine receptor (nAChR) to undergo agonist-induced conformational transitions requires the presence of...
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Protein networking: nicotinic acetylcholine receptors and their protein–protein-associations
Nicotinic acetylcholine receptors (nAChR) are complex transmembrane proteins involved in neurotransmission in the nervous system and at the...
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Muscle gene expression of CGRP-α, CGRP receptor, nAchR-β, and GDNF in response to different endurance training protocols of Wistar rats
The neuromuscular junction underwent adaptations to meet the demands of muscles following increased muscle activity. This study aimed to investigate...
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A New Protein Glosaxin Composed of Noncatalytic Domains of Class PIII Metalloproteinase from the Pit Viper Gloydius saxatilis Venom Inhibits Nicotinic Acetylcholine Receptor
AbstractObjective: Although main components of the venoms from Viperidae snakes are hemotoxins, several studies indicate the presence of neurotoxins...
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Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum
AbstractAlzheimer’s disease is a rapidly progressive neurodegenerative disease, the development of which is associated with the accumulation of...
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Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech
Recent work putatively linked a rare genetic variant of the chaperone Resistant to Inhibitors of acetylcholinesterase ( RIC3 ) (NM_024557.4:c.262G > A,...
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Human Epithelial Protein SLURP-2 as a Prototype of Drugs for Wound Healing
AbstractObjective: Wound healing is a complex process based on the regulation of proliferation and migration of epithelial cells. Chronic wounds are...
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Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor (nAChR), a potential drug target for treating cognitive disorders, mediates communication between neuronal...
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Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
Nicotinic acetylcholine receptor of α7 type (α7-nAChR) presented in the nervous and immune systems and epithelium is a promising therapeutic target...
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Cannabidiol as a modulator of α7 nicotinic receptors
Cannabidiol (CBD), an important terpenoid compound from marijuana with no psychoactive effects, has become of great pharmaceutical interest for...
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Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling
BackgroundImmunotherapy has proven to be an emerging treatment for non-small-cell lung cancer in recent years. Notably, smokers show higher...
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From Peptides to Receptors
Abstract—In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically...
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Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor is a member of the nicotinic acetylcholine receptor family and is composed of five α7 subunits arranged...
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Vagus nerve stimulation exerts cardioprotection against doxorubicin-induced cardiotoxicity through inhibition of programmed cell death pathways
The aberration of programmed cell death including cell death associated with autophagy/mitophagy, apoptosis, necroptosis, pyroptosis, and ferroptosis...
