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miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid...
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Spheroid architecture strongly enhances miR-221/222 expression and promotes oxidative phosphorylation in an ovarian cancer cell line through a mechanism that includes restriction of miR-9 expression
BackgroundTumor cell spheroids are organized multicellular structures that form during the expansive growth of carcinoma cells. Spheroids formation...
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Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis
Previous studies in our laboratory have reported that miR-222-3p was a tumor-suppressive miRNA in OC. This study aims to further understand the...
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Circ_0003159 upregulates LIFR expression through competitively binding to miR-221-3p/miR-222-3p to block gastric cancer development
Gastric cancer (GC) remains a major cause of cancer-related deaths. Increasing studies suggest that cancer development is accompanied by the...
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miR-222-3p-containing macrophage-derived extracellular vesicles confer gemcitabine resistance via TSC1-mediated mTOR/AKT/PI3K pathway in pancreatic cancer
Gemcitabine resistance limits the efficacy of chemotherapy and maintains a challenge for treatment outcomes. Therefore, we aimed to clarify the...
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METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
BackgroundMETTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a...
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Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis
Exosomal miRNAs activates hepatic stellate cell (HSC) and promote fibrosis. miR-222 was found to be increased in hepatitis B virus (HBV)-infected...
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Influence of miR-221/222 on cardiomyocyte calcium handling and function
BackgroundCardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and...
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Identification of miR-17, miR-21, miR-27a, miR-106b and miR-222 as endoplasmic reticulum stress-related potential biomarkers in circulation of patients with atherosclerosis
Atherosclerosis and related cardiovascular diseases are among the most common causes of death worldwide. Unfolded protein response, also known as...
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MiR-222-3p induced by hepatitis B virus promotes the proliferation and inhibits apoptosis in hepatocellular carcinoma by upregulating THBS1
This study aimed to explore the role of miR-222-3p in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). MiR-222-3p expression in tumor...
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Serotonin-induced miR-221/222 contribute to the activation of hepatic stellate cells
In the diseased liver, hepatic stellate cells (HSCs) transdifferentiate into “activated” myofibroblasts that then drive fibrogenesis by promoting the...
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MiR-222 inhibition alleviates Staphylococcal Enterotoxin B-induced inflammatory acute lung injury by targeting Foxo3
Acute lung injury (ALI) is a common acute and severe disease in clinical practice. Staphylococcal Enterotoxin B (SEB) is a superantigen that can...
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LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis
BackgroundPulmonary arterial hypertension (PAH) is often characterized by cell proliferation and migration of pulmonary arterial smooth muscle cells...
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Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma
Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts,...
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miR-221 and -222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density
MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among others cardiac hypertrophy and atrial fibrillation. The aim of...
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Exosomes derived from M1 macrophages aggravate neointimal hyperplasia following carotid artery injuries in mice through miR-222/CDKN1B/CDKN1C pathway
The role of M1 macrophages (M1M)-derived exosomes in the progression of neointimal hyperplasia remains unclear now. Using a transwell co-culture...
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Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p
Male reproductive diseases are becoming increasingly prominent, and sperm quality is an important indicator to reflect these diseases. Seminal plasma...
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Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis
IntroductionWhite Stri** (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for contemporary broiler production worldwide....
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Association between extract of Euphorbia szovitsii and expression level of microRNAs in MDA-MB-231 cell line
BackgroundThe miRNAs have been shown to be involved in breast cancer. The aim of the present research was to evaluate the impacts of extract from Euph...
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MiR-222-3p Regulates the Proliferation and Differentiation of C2C12 Myoblasts by Targeting BTG2
AbstractMiR-222-3p has been implicated in tumor cell proliferation and has an important role in the differentiation and maturation of myogenic cells....
