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A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment
For more than seven decades, methotrexate has been used all over the world for treatment of different diseases such as: cancer, autoimmune diseases,...
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Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate
BACKGROUND:Rheumatoid arthritis (RA) is characterized by chronic inflammation and joint damage. Methotrexate (MTX), a commonly used disease-modifying...
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Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries
Accumulating data confirms that Methotrexate (MTX), a well-known immunosuppressive and anticancer drug, causes nephrotoxicity. Infliximab (INF), the...
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Possible ameliorative effect of human placental extract on methotrexate-induced nephrotoxicity in albino rats
BackgroundMethotrexate (MTX) is one of chemotherapeutic drugs that induce several side effects. The present study aimed to investigate the...
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Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
BackgroundOrgan toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an...
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Characterization of 36-kDa Dimeric Methotrexate-degrading Enzyme from Variovorax paradoxus, its Performance and Stability of its Cross-linked Aggregates
AbstractIn the present study, methotrexate (MTX)-degrading 36-kDa dimer was characterized from the 0–80% ammonium sulphate precipitate of Variovorax...
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Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity
Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In...
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Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats
BackgroundMethotrexate (MTX), a chemotherapeutic agent, is known to cause oral mucositis. Chitosan has been shown to have a protective effect in...
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Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
Metformin, the first-line drug for type II diabetes, has recently been considered an anticancer agent. However, the molecular target and underlying...
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The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats
BackgroundMethotrexate (MT) is a broadly used chemotherapeutic drug however its clinical use is confronted with several forms of toxicities...
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The Effect of Methotrexate on Serum Levels of Trace/Mineral Elements in Patients with Psoriatic Arthritis
Psoriatic arthritis is a type of inflammatory arthritis that occurs in some patients with psoriasis. Clinically, low-dose methotrexate was used to...
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Molecular mechanism of action and pharmacokinetic properties of methotrexate
Since its discovery in 1945, methotrexate has become a standard therapy for number of diseases, including oncological, inflammatory and pulmonary...
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Clinical and Radiological Characterization of Patients with Immobilizing and Progressive Stress Fractures in Methotrexate Osteopathy
Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects...
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Alterations in the matrix metalloproteinase-3 promoter methylation after common chemotherapeutics: in vitro study of paclitaxel, cisplatin and methotrexate in the MCF-7 and SH-SY5Y cell lines
Cancer treatment is a complex process due to the several encountered obstacles during therapy, such as metastasis, angiogenesis, and drug resistance....
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Designing a novel drug–drug conjugate as a prodrug for breast cancer therapy: in silico insights
Breast cancer (BC) poses a significant global health threat, necessitating innovative therapeutic approaches. The ribosomal s6 kinase 2 (RSK2) has...
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Clinical Manifestations and Prognosis of Giant Cell Arteritis: A Retrospective Cohort Study
AbstractThe aim of the study was to evaluate the clinical manifestations and survival of patients with giant cell arteritis (GCA).
Materials and...
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Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms
BackgroundMethotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic...
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Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy
Cytotoxicity (i.e. cell death) is the core mechanism by which chemotherapy induces its anti-cancer effects. Unfortunately, this same mechanism...
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Design, Synthesis, Computational, and In Vitro Cytotoxic Potential of Novel 5,7,8,9-Tetrahydrotetrazolo[5,1-b]quinazolines Analogs
AbstractObjective: Quinazolines and condensed quinazolines got a significant role to be treated as the pharmacophore nucleus for various diseases by...
