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Clinical Trials with Stem Cell-Derived Insulin-Producing Cells
Because of the real-time physiological glucose sensing and synchronized insulin secretion, the replacement of β-cell mass through transplantation has...
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Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
BackgroundDiabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1...
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Bioengineered Vascularized Insulin Producing Endocrine Tissues
Islet transplantation is a promising treatment for type 1 diabetes (T1D), but limited islet engraftment hampers its success. In vivo, islets require...
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Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
ObjectiveIn recent years, cell therapy has emerged as a new research direction in the treatment of diabetes. However, the underlying molecular...
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Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors
Direct lineage reprogramming of one somatic cell into another without transitioning through a progenitor stage has emerged as a strategy to generate...
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Vitamin D supplementation affects bone marrow-derived mesenchymal stem cells differentiation into insulin-producing cells
Background this study was conducted to assess the effects of vitamin D on differentiation of bone marrow- derived mesenchymal stem cells (BM-MSCs)...
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Insulin-producing cell clusters derived from human gingival mesenchymal stem cells as a model for diabetes research
BackgroundThe human gingiva-derived mesenchymal stem cells (hGMSCs) possess a great potential to develop the cell-based therapy for diabetes due to...
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The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
BackgroundDiabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia....
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Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges
Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune destruction of insulin-producing β -pancreatic cells. Although many...
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PCSK9 inhibition and cholesterol homeostasis in insulin producing β-cells
Low-density lipoprotein cholesterol (LDL-C) plays a central role in the pathology of atherosclerotic cardiovascular disease. For decades, the gold...
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Morphofunctional Characteristic of Insulin-Producing Cells of Different Localization in the Pancreas of Intact Rats
Abstract —This study is devoted to a comparison of morphofunctional peculiarities and the ratio of apoptosis and proliferation processes in the...
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New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells
Differentiation of human pluripotent stem cells into insulin-producing stem cell-derived beta cells harbors great potential for research and therapy...
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Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice
BackgroundThe purpose of this study was to investigate allogenic immune responses following the transplantation of insulin-producing cells (IPCs)...
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MYCL-mediated reprogramming expands pancreatic insulin-producing cells
β cells have a limited capacity for regeneration, which predisposes towards diabetes. Here, we show that, of the MYC family members, Mycl plays a key...
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Generation of insulin-producing pancreatic β cells from multiple human stem cell lines
We detail a six-stage planar differentiation methodology for generating human pluripotent stem cell–derived pancreatic β cells (SC-β cells) that...
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Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation
Type 1 diabetes is a life-threatening disease that is hallmarked by an autoimmune response against the insulin-producing β-cells in the pancreatic...
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Minimal SC-β-Cell Properties for Transplantation in Diabetic Patients
Pancreatic β cells within the islets of Langerhans are the body’s main source for insulin. β cells maintain glucose homeostasis through the tight...
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Improvement of the therapeutic capacity of insulin-producing cells trans-differentiated from human liver cells using engineered cell sheet
BackgroundAlthough pancreatic islet transplantation therapy is ideal for diabetes patients, several hurdles have prevented it from becoming a...
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Current status of stem cell therapy for type 1 diabetes: a critique and a prospective consideration
Over the past decade, there had been progress in the development of cell therapy for insulin-dependent diabetes. Nevertheless, important hurdles that...
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Transcriptome analysis of the transdifferentiation of canine BMSCs into insulin producing cells
BackgroundBone marrow mesenchymal stem cells are a potential resource for the clinical therapy of certain diseases. Canine, as a companion animal,...
