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The Theory of Gene Family Histories
Most genes are part of larger families of evolutionary-related genes. The history of gene families typically involves duplications and losses of...
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Molecular evolution of transcription factors AF4/FMR2 family member (AFF) gene family and the role of lamprey AFF3 in cell proliferation
AF4/FMR2 family member (AFF) proteins are a group of transcriptional regulators that can regulate gene transcription and play an important role in...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Genome-wide identification and analysis of the cotton ALDH gene family
BackgroundAldehyde dehydrogenases (ALDHs) are a family of enzymes that catalyze the oxidation of aldehyde molecules into the corresponding carboxylic...
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Identification and expression analysis of XIP gene family members in rice
Xylanase inhibitor proteins (XIP) are widely distributed in the plant kingdom, and also exist in rice. However, a systematic bioinformatics analysis...
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Dynamic evolution of the mTHF gene family associated with primary metabolism across life
BackgroundThe folate cycle of one-carbon (C1) metabolism, which plays a central role in the biosynthesis of nucleotides and amino acids, demonstrates...
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Genome-wide identification, molecular evolution and gene expression of P450 gene family in Cyrtotrachelus buqueti
BackgroundInsect Cytochrome P450 monooxygenase ( CYPs or P450 s) plays an important role in detoxifying insecticides, causing insect populations to...
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Genome-wide analysis of filamentous temperature-sensitive H protease (ftsH) gene family in soybean
BackgroundThe filamentous temperature-sensitive H protease ( ftsH ) gene family belongs to the ATP-dependent zinc metalloproteins, and ftsH genes play...
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Molecular evolution of the hemoglobin gene family across vertebrates
Adaptation to various altitudes and oxygen levels is a major aspect of vertebrate evolution. Hemoglobin is an erythrocyte protein belonging to the...
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The ABC1K gene family in Chinese cabbage: phylogeny, structure and function
The ABC1K gene family (activity of BC1 complex kinase), found in bacteria, archaea, and eukaryotes, plays a vital role in regulating cellular...
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Approaches to increase the validity of gene family identification using manual homology search tools
Identifying homologs is an important process in the analysis of genetic patterns underlying traits and evolutionary relationships among species....
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Genome-wide analysis and expression profiling of the HD-ZIP gene family in kiwifruit
The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive...
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GH2 family β-galactosidases evolution using degenerate oligonucleotide gene shuffling
ObjectivesTo improve the biochemical characteristics of the GH2 family β-galactosidases using a family shuffling method based on degenerate...
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Origin, evolution, and diversification of the wall-associated kinase gene family in plants
Key message The study of the origin, evolution, and diversification of the wall-associated kinase gene family in plants facilitates their functional...
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Genome-wide identification and evolutionary analysis of the NRAMP gene family in the AC genomes of Brassica species
BackgroundBrassica napus , a hybrid resulting from the crossing of Brassica rapa and Brassica oleracea , is one of the most important oil crops....
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Automatic annotation of the bHLH gene family in plants
BackgroundThe bHLH transcription factor family is named after the basic helix-loop-helix (bHLH) domain that is a characteristic element of their...
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Bioinformatics and expression analysis of the NRL gene family in Populus trichocarpa
Populus trichocarpa (black cottonwood) is a fast-growing deciduous tree from the willow family (Salicaceae) grown for its fiber products and timber....
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Genome-wide identification of grape ANS gene family and expression analysis at different fruit coloration stages
BackgroundAnthocyanin synthase (ANS) is the enzyme downstream of the anthocyanins synthesis pathway and the rate-limiting enzyme of the synthesis...
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Genome-Wide Identification, Structural Analysis, and Expression Patterns of Tomato SRS Gene Family
Short internodes-related sequence (SRS) family genes are important regulators in multiple growth and development programs. However, the SRS gene...
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Single nucleotide polymorphisms in the MRFs gene family associated with growth in Nile tilapia
BackgroundMuscle occupies most of the fish body, promoting the proliferation of fish muscle fibers can facilitate rapid growth and increase the body...
