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Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although Fas is highly expressed in cancer cells,...
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Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer
Receptor clustering is the most critical step to activate extrinsic apoptosis by death receptors belonging to the TNF superfamily. Although...
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Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts
Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising...
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Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition
Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their mechanism of action is not well understood. Decoding the...
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FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis
Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related...
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Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4+ T cells and is regulated by Fas/FasL signaling
Mitochondrial activation and the production of mitochondrial reactive oxygen species (mROS) are crucial for CD4 + T cell responses and have a role in...
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Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms
Sirt6, a class III NAD + -dependent deacetylase of the sirtuin family, is a highly specific H3 deacetylase and plays important roles in regulating...
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Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis
Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and...
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Bifidobacterium animalis sup F1-7 Acts as an Effective Activator to Regulate Immune Response Via Casepase-3 and Bak of FAS/CD95 Pathway
Intestinal microecology was closely related to immune regulation, but the related mechanism was still unclear. This study aimed to reveal how...
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Resistance to obinutuzumab-induced antibody-dependent cellular cytotoxicity caused by abnormal Fas signaling is overcome by combination therapies
BackgroundObinutuzumab, a Type II anti-CD20 antibody, is used to treat follicular lymphoma. A major mode of action of obinutuzumab is...
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AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway
Hepatocellular carcinoma (HCC) is a major leading cause of cancer-related death worldwide. Alpha fetoprotein (AFP) is reactivated in a majority of...
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Using NMR Titration Experiments to Study E. coli FAS-II- and AcpP-Mediated Protein–Protein Interactions
Acyl carrier proteins (ACPs) are central to many primary and secondary metabolic pathways. In E. coli fatty acid biosynthesis (FAB), the central ACP,...
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miR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling
Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p , and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC)...
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Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS) is a primary disorder of lymphocyte homeostasis, leading to chronic lymphoproliferation, autoimmune...
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Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae
Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these...
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Foraging areas of Orlog’s gulls in an estuarine ecosystem of Argentina: are they underprotected?
Worldwide, seabird populations are facing significant declines due to various threats, making them valuable bioindicators of marine ecosystem...
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Adaptation of Litoral Halophytes to the Conditions of the Coastal Territories of the White Sea: Involvement of Fatty Acid Composition of Lipids
AbstractThe authors studied the composition of fatty acids (FAs) in four species of dominant obligate halophytes— Triglochin maritima , Plantago...
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Probing the ER-Focal Adhesion Link During Cell Migration
Focal adhesions (FAs) are contact points of the cell with the extracellular matrix (ECM) and play a major role in several cellular functions...
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Futile lipid cycling: from biochemistry to physiology
In the healthy state, the fat stored in our body isn’t just inert. Rather, it is dynamically mobilized to maintain an adequate concentration of fatty...
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Peroxidation of unsaturated fatty acids is associated with poor storability in onion seed
Onion seeds have one of the lowest storability among the cultivated crops. In this study, two onion varieties, Bhima Safed (BSD), a good storer, and...
