Search
Search Results
-
Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation
Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy...
-
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that...
-
Electrical pulse stimulation parameters modulate N2a neuronal differentiation
Electrical pulse stimulation has been used to enhance the differentiation or proliferation of neuronal progenitor cells in tissue engineering and...
-
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Purpose of ReviewThe underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an area of...
-
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
Autophagy, a critical catabolic process for cell survival against different types of stress, has a role in the differentiation of various cells, such...
-
Molecular and Cellular Mechanisms Governing Adipogenic Differentiation
AbstractAdipose tissue is a special type of connective tissue that comprises stromal-vascular cells, committed preadipocytes, and mature adipocytes....
-
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Proneural genes play a crucial role in neuronal differentiation. However, our understanding of the regulatory mechanisms governing proneural genes...
-
Direct differentiation of tonsillar biopsy-derived stem cells to the neuronal lineage
BackgroundNeurological disorders are considered one of the greatest burdens to global public health and a leading cause of death. Stem cell therapies...
-
Trained innate immunity modulates osteoblast and osteoclast differentiation
Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts...
-
Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more...
-
Plant regeneration through two pathways of direct organogenesis in Paeonia ostii ‘Feng Dan’
Tissue culture is preferred for solving the shortcomings of low efficiency of conventional propagation in tree peony ( Paeonia sect. Moutan ), an...
-
Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation
Histone methylation plays a crucial role in various cellular processes. We previously reported the in vitro function of histone lysine demethylase...
-
Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells
Trisomy 12 is one of the most frequent chromosomal abnormalities in cultured human pluripotent stem cells (hPSCs). Although potential oncogenic...
-
Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation
FAM20C phosphorylates secretory proteins at S-x-E/pS motifs, and previous studies of Fam20C-dificient mice revealed that FAM20C played essential...
-
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process...
-
Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
BackgroundAfter myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial...
-
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible...
-
BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation
Bromodomain containing protein 9 (BRD9), a member of the non-canonical BRG1/BRM-associated factor (ncBAF) chromatin remodeling complex, has been...
-
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
-
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development
The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates...
