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Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes
2,5-Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected via two peptide bonds. They can be biosynthesized in...
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Assay of Endocannabinoid Oxidation by Cytochrome P450
Cytochrome P450 enzymes are a large family of heme-containing proteins that have important functions in the biotransformation of xenobiotics,...
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Role of Cytochrome P450 in Xenobiotic Metabolism in Fishes (Review)
Cytochrome P450 (CYP) enzymes encompass a family of heme proteins which plays a prime role in the biotransformation of broad range of exogenous and...
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Cytochrome P450 for environmental remediation: catalytic mechanism, engineering strategies and future prospects
Environmental pollution is a global concern. Various organic compounds are released into the environment through wastewater, waste gas, and waste...
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Identification and characterization of cytochrome P450 CYP77A59 of loquat (Rhaphiolepis bibas) responsible for biosynthesis of phenylacetonitrile, a floral nitrile compound
Main conclusionCytochrome P450 CYP77A59 is responsible for the biosynthesis of phenylacetonitrile in loquat flowers.
AbstractFlowers of some plants...
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Plant cytochrome P450s directing monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) biosynthesis
The large family of cytochrome P450 enzymes are heme containing proteins generally associated with the cytoplasmic face of the endoplasmic reticulum...
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A Chemoenzymatic Approach to Investigate Cytochrome P450 Cross-Linking in Glycopeptide Antibiotic Biosynthesis
Glycopeptide antibiotics (GPAs) are important and medically relevant peptide natural products. In the context of antimicrobial resistance (AMR),...
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16R-HETE and 16S-HETE alter human cytochrome P450 1B1 enzyme activity probably through an allosteric mechanism
Cytochrome P450 1B1 (CYP1B1) has been widely associated with the development of cardiac pathologies due to its ability to produce cardiotoxic...
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Spectral features of the ferrous–CO complex in cytochrome P450: a revisit using TDDFT calculations
There are different views in the literature regarding how to interpret the observed spectral features of the ferrous–CO complexes in cytochrome P450...
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Overexpression of chaperones GroEL/ES from Escherichia coli enhances indigo biotransformation production of cytochrome P450 BM3 mutant
The self-sufficient cytochrome P450 BM3 mutant (A74G/F87V/D168H/L188Q) can serve as a biocatalyst for whole-cell catalysis process of indigo....
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Genome-wide identification, comparative analysis and functional roles in flavonoid biosynthesis of cytochrome P450 superfamily in pear (Pyrus spp.)
BackgroundThe cytochrome P450 (CYP) superfamily is the largest enzyme metabolism family in plants identified to date, and it is involved in many...
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The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan
BackgroundPharmacogenomics (PGx) plays a central role in the selection of targeted therapies that underpins precision-medicine. We investigated the...
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VDR promotes testosterone synthesis in mouse Leydig cells via regulation of cholesterol side chain cleavage cytochrome P450 (Cyp11a1) expression
BackgroundThe vitamin D receptor (VDR) mediates the pleiotropic biological actions that include osteoporosis, immune responses and androgen...
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Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1
BackgroundBisphenol A (BPA) is a rapid spreading organic pollutant that widely used in many industries especially as a plasticizer in polycarbonate...
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Three novel mutations in CYB5R3 gene causing NADH-cytochrome b5 reductase enzyme deficiency leads to recessive congenital methaemoglobinemia
BackgroundMethemoglobin is the reduced form of haemoglobin that is normally found in the blood in levels < 1%. Methemoglobinemia can occur as a...
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Ectopic expression of MmCYP1A1, a mouse cytochrome P450 gene, positively regulates stress tolerance in apple calli and Arabidopsis
Key messageEctopic expression of MmCYP1A1 gene from Mus musculus in apple calli and Arabidopsis increased the levels of melatonin and...
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Trichoplusia ni Transcriptomic Responses to the Phytosaponin Aglycone Hederagenin: Sex-Related Differences
Many plant species, particularly legumes, protect themselves with saponins. Previously, a correlation was observed between levels of oleanolic...
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The cytochrome b6f complex: plastoquinol oxidation and regulation of electron transport in chloroplasts
In oxygenic photosynthetic systems, the cytochrome b 6 f (Cyt b 6 f ) complex (plastoquinol:plastocyanin oxidoreductase) is a heart of the hub that...
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Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution
Most P450s require redox partners for the electron transfer during catalysis. However, little information is available on cognate redox partners for...
