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Relationship between heart failure and intestinal inflammation in infants with congenital heart disease
ObjectiveThe association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with...
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Association between placental DNA methylation and fetal congenital heart disease
Congenital heart disease (CHD) is a worldwide problem with high morbidity and mortality. Early diagnosis of congenital heart disease is still a...
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Congenital Heart Defects Which Include Cardiac Valve Abnormalities
Atrioventricular or semilunar valve disease can be an isolated congenital heart abnormality, but may also occur as part of a more complex congenital...
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Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
BackgroundGenomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of...
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Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease
Congenital heart disease (CHD) represents a significant risk factor with profound implications for neonatal survival rates and the overall well-being...
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Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish
Congenital heart disease (CHD) is the most common birth defect worldwide and a main cause of perinatal and infant mortality. Our previous genome-wide...
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Plasma metabolomic and lipidomic profiles accurately classify mothers of children with congenital heart disease: an observational study
IntroductionCongenital heart disease (CHD) is the most common congenital anomaly, representing a significant global disease burden. Limitations exist...
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Copy number variation-associated lncRNAs may contribute to the etiologies of congenital heart disease
Copy number variations (CNVs) have long been recognized as pathogenic factors for congenital heart disease (CHD). Few CHD associated CNVs could be...
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Deep sequencing unveils altered cardiac miRNome in congenital heart disease
AbstractCongenital heart disease (CHD) surges from fetal cardiac dysmorphogenesis and chiefly contributes to perinatal morbidity and cardiovascular...
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Heart Valve Disease
This chapter was designed to provide the reader with a brief overview of the current treatment options for human heart valve disease. Major topics of...
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Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease
For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve...
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Novel and deleterious nucleotide variations in the HAND1 gene probably affect miRNA target sites and protein function in pediatric patients with congenital heart disease
BackgroundCongenital heart disease (CHD) is the most prevalent developmental defect and principal cause of infant mortality and affects cardiac and...
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Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies
BackgroundCongenital heart defects (CHDs) are the most common birth defects. Assessment of the incidence, distribution, disease spectrum, and genetic...
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Gene-Interaction-Sensitive enrichment analysis in congenital heart disease
BackgroundGene set enrichment analysis (GSEA) uses gene-level univariate associations to identify gene set-phenotype associations for hypothesis...
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High throughput mutation screening of cardiac transcription factor GATA4 among Tanzania children with congenital heart diseases
Congenital heart disorders (CHDs) are common, estimated to affect 8 out of every 1000 live births, and they are associated with high mortality and...
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Preservation of human heart valves for replacement in children with heart valve disease: past, present and future
Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic...
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Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy
Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and...
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Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress
Phosphodiesterase 2A (Pde2A) is a dual-specific PDE that breaks down both cAMP and cGMP cyclic nucleotides. We recently highlighted a direct...
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Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects
BackgroundCongenital heart defects (CHD) are structural defects of the heart affecting approximately 1% of newborns. They exhibit low penetrance and...
