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Genome-wide chromatin accessibility landscape and dynamics of transcription factor networks during ovule and fiber development in cotton
BackgroundThe development of cotton fiber is regulated by the orchestrated binding of regulatory proteins to cis -regulatory elements associated with...
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The Nodewalk assay to quantitate chromatin fiber interactomes in very small cell populations
The chromosome conformation capture method and its derivatives, such as circularized chromosome conformation capture, carbon copy chromosome...
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Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics
Our understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last few years. High-resolution...
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Transcription modulates chromatin dynamics and locus configuration sampling
In living cells, the 3D structure of gene loci is dynamic, but this is not revealed by 3C and FISH experiments in fixed samples, leaving a notable...
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Dynamic 3D genome architecture of cotton fiber reveals subgenome-coordinated chromatin topology for 4-staged single-cell differentiation
BackgroundDespite remarkable advances in our knowledge of epigenetically mediated transcriptional programming of cell differentiation in plants,...
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The Roles of Chromatin Remodelling Factors in Replication
Dynamic changes of chromatin structure control DNA-dependent events, including DNA replication. Along with DNA, chromatin organization must be...
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Analysis of long-range chromatin contacts, compartments and loo** between mouse embryonic stem cells, lens epithelium and lens fibers
BackgroundNuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments,...
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Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
BackgroundCellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. DNA methylation...
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Chromatin remodelers: a concise introduction for biophysicists
Chromatin remodelers are molecular motors that act on nucleosomes: they move them along DNA or (dis-)assemble them. Despite the fact that they...
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Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes
The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like...
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Histone H1.0 couples cellular mechanical behaviors to chromatin structure
Tuning of genome structure and function is accomplished by chromatin-binding proteins, which determine the transcriptome and phenotype of the cell....
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Chromatin balances cell redox and energy homeostasis
Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and...
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Regulation of chromatin architecture by protein binding: insights from molecular modeling
Histone and non-histone proteins play key roles in the activation and repression of genes. In addition to experimental studies of their regulation of...
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Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler
Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes. However, our understanding of how these processes (for...
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Interphase epichromatin: last refuge for the 30-nm chromatin fiber?
“Interphase epichromatin” describes the surface of chromatin located adjacent to the interphase nuclear envelope. It was discovered in 2011 using a...
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Phosphorylation regulates tau’s phase separation behavior and interactions with chromatin
Tau is a microtubule-associated protein often found in neurofibrillary tangles (NFTs) in the brains of patients with Alzheimer’s disease. Beyond this...
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The Role of CTCF-Mediated Chromatin Loo** in Enhancer-Promoter Communication
In vertebrates, gene transcription is performed by generic eukaryotic molecular machinery under influence of sequence-specific DNA-binding...
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MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken
BackgroundSkeletal muscle development is pivotal for animal growth and health. Recently, long noncoding RNAs (lncRNAs) were found to interact with...
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Vertebrate centromere architecture: from chromatin threads to functional structures
Centromeres are chromatin structures specialized in sister chromatid cohesion, kinetochore assembly, and microtubule attachment during chromosome...
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Functional Aspects of Sperm Chromatin Organization
Sperm nuclei present a highly organized and condensed chromatin due to the interchange of histones by protamines during spermiogenesis. This high DNA...