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Chemical Synthesis of Gangliosides
Synthetic methodologies for gangliosides have evolved over the past three decades. The strategies for constructing ganglioside skeletons can...
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Chemical Synthesis of Phosphatidylglucoside
1-stearoyl (18:0)-2-arachidoyl (20:0)-sn-glycero-3-phospho-ß-D-glucoside (Phosphatidylglucoside or PtdGlc) was synthesized by direct coupling of...
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Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis
Chemical ligation can be used to install encoding tags during the synthesis of DNA-encoded chemical libraries and can present a number of advantages....
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Chemical Synthesis of Oligonucelotide Sequences: Phosphoramidite Chemistry
Oligonucleotides are used in a variety of molecular biology techniques, from next-generation sequencing to genetic testing. Maintaining the sequence...
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Ribosomal Synthesis of Peptides Bearing Noncanonical Backbone Structures via Chemical Posttranslational Modifications
Noncanonical peptide backbone structures, such as heterocycles and non-α-amino acids, are characteristic building blocks present in peptidic natural...
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Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As
Lipopolysaccharide (LPS), a cell surface component of Gram-negative bacteria, and its active principle, lipid A, have immunostimulatory properties...
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Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural...
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Peptide Synthesis
Peptide synthesis is characterized by forming a substituted amide linkage between two amino acids. The first successful attempt to synthetically link...
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Design and Synthesis of Ubiquitin-Based Chemical Tools with Unnatural Amino Acids for Selective Detection of Deubiquitinases
Several chemical approaches have been applied to develop Ub-based substrates and probes selective toward one or a narrow subset of deubiquitinases...
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Preparation of Mucin Glycopeptides by Organic Synthesis
Mucins are sugar-rich glycoproteins. Glycoprotein sugar moieties are structurally diverse, making it difficult to obtain naturally pure...
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Fmoc Solid-Phase Peptide Synthesis
Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide...
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Synthesis of Nanoparticles by Microbes
Modern life is not conceivable without the involvement of nanoparticles. Major aspects of science are dependent on nanotechnology for varied...
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Chemical Synthesis and Molecular Interaction Analysis of α-Galactosyl Ceramide Derivatives as CD1d Ligands
CD1d is a non-classical major histocompatibility complex (MHC) protein, responsible for lipid antigen presentation, which presents lipids to natural...
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Chemical Synthesis of PDZ Domains
Developments in chemical protein synthesis have enabled the generation of tailor-made proteins including incorporation of many types of modifications...
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Exosomes: Biogenesis, Composition, and Synthesis
Exosomes are tiny, membrane-bound vesicles that are present in many body fluids and perform important functions in cell-to-cell communication. The...
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Modelling Chemical Reactions
The aim of this chapter is to summarize and review the main conceptual frameworks in which models of biochemical networks can be developed. The...
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Library Synthesis and Analytics
DNA-encoded library synthesis is an evolved combinatorial synthesis, using a split-and-pool strategy in 96-well plates, libraries containing millions...
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Biochemistry of Hyaluronan Synthesis
Hyaluronan (HA) is a ubiquitous component of the extracellular matrix and cell microenvironment made of β D-Glucuronic acid and...
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Template-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver...
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DNA-Encoded Chemical Libraries Methods and Protocols
This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this...