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Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation
Low sperm motility is a significant contributor to male infertility. beta-defensins have been implicated in host defence and the acquisition of sperm...
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Transcriptomic profiling of the develo** brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress
BackgroundPrenatal stress (PS) is considered as a risk factor for many mental disorders. PS-induced transcriptomic alterations may contribute to the...
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Specificity of Growth and Accumulation of Flavonoids in Plants and Cell Cultures of Lychnis chalcedonica Obtained from Explants of Different Organs
AbstractFlavonoids have numerous functions in plants, one of which is growth regulation. During the study, callus cultures were obtained from...
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DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity
Precision pharmacology aims to manipulate specific cellular interactions within complex tissues. In this pursuit, we introduce DART.2 (drug acutely...
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Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
BackgroundAlthough interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been investigated. In...
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Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
CD8 + T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By...
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Evolution of a plant growth-regulatory protein interaction specificity
Specific protein–protein interactions (PPIs) enable biological regulation. However, the evolution of PPI specificity is little understood. Here we...
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Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated...
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ArdA Protein Specificity against Type I Restriction–Modification Systems
AbstractThe ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead of DNA to RMI. The ArdA...
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SwarmTCR: a computational approach to predict the specificity of T cell receptors
BackgroundWith more T cell receptor sequence data becoming available, the need for bioinformatics approaches to predict T cell receptor specificity...
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Selection of extended CRISPR RNAs with enhanced targeting and specificity
As CRISPR effectors like Cas9 increasingly enter clinical trials for therapeutic gene editing, a future for personalized medicine will require...
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An activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is...
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Oligomeric Structure of Yeast and Other Invertases Governs Specificity
Invertases, or β-fructofuranosidases, are metabolic enzymes widely distributed among plants and microorganisms that hydrolyze sucrose and release...
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Moonlighting enzymes: when cellular context defines specificity
It is not often realized that the absolute protein specificity is an exception rather than a rule. Two major kinds of protein multi-specificities are...
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Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins
Anti-DNA antibodies (Abs), serological hallmarks of systemic lupus erythematosus (SLE) and markers for diagnosis and disease activity, show a...
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Examining Galectin Binding Specificity Using Glycan Microarrays
Glycan binding proteins (GBPs) possess the unique ability to regulate a wide variety of biological processes through interactions with highly...
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Plant–Fungal Interactions: Laser Microdissection as a Tool to Study Cell Specificity
In the past 20 years, laser microdissection (LMD) technology has been widely applied to plant tissues, allowing to obtain new information on the role...
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Cell Cycle–Specific Protein Phosphatase 1 (PP1) Substrates Identification Using Genetically Modified Cell Lines
The identification of protein phosphatase 1 (PP1) holoenzyme substrates has proven to be a challenging task. PP1 can form different holoenzyme...
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GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic...
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Dual-specificity Tyrosine Phosphorylation-regulated Kinase Inhibitor ID-8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression
BackgroundHuman induced pluripotent stem cells (hiPSCs) hold great potentials in disease modeling, drug screening and cell therapy. However,...
