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Utility of arylglyoxal hydrates in synthesis of 4-aroyl-[1,3,5]triazino[1,2-a]benzimidazol-2(1H)-imines and 5-aryl-2-phenyl-4H-imidazol-4-imines
AbstractNucleophilic substitution reaction for arylglyoxal hydrates (AGs-hydrate) was studied via their reaction with some mono- and...
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Design and synthesis of novel N-[3-(benzimidazol-2-ylamino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives as potential anticancer agents
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N -[3-(benzimidazol-2-yl-amino)phenyl]amine and N -[3-(ben...
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Synthesis and Urease Inhibition Activities of Some New Schiff Bases Benzimidazoles Containing Thiophene Ring
AbstractObjective: Schiff bases are significant pharmacophores and show varied biological applications such as antiurease, antidiabetic,...
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Synthesis and Docking Studies of Novel Benzimidazole Derivatives Containing Thiophene and Triazole Rings as Potential Urease Inhibitors
AbstractA new series of 5,6-dichloro-benzimidazoles containing thiophene ring derivatives of thiosemicarbazides and triazoles were designed,...
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Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold
AbstractNew hydrazinylidene derivatives were synthesized under appropriate conditions and in excellent yields, by the reaction between a new...
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Design, Synthesis, and Anti-Breast Cancer Activity of Some Hybrid Molecules Containing Coumarin Moiety
Abstract(Benzimidazol-2-yl)-7-hydroxycoumarin and N -(2-hydroxyphenyl)-7-hydroxycoumarin-3-carboxamide have been synthesized by the condensation of...
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Microbial degradation of the benzimidazole fungicide carbendazim by Bacillus velezensis HY-3479
Carbendazim (methyl benzimidazol-2-ylcarbamate: MBC) is a fungicide of the benzimidazole group that is widely used in the cultivation of pepper,...
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Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors
AbstractIn this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for...
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Volatile profiling of cacti: a preliminary assessment of the taxonomic and evolutionary significance of volatile compounds in Cylindropuntia, Grusonia, Consolea, Opuntia, Quiabentia, and Tacinga
Volatile analyses of cacti have previously been performed on the flowers, fruits, and consumed stems. During our own investigations, we and others...
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Design, synthesis, and computational studies of phenylacetamides as antidepressant agents
In the present work, a hit molecule obtained from zinc ‘clean drug-like database’ by systematically performed computational studies was modified...
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Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole Moiety
AbstractReaction of 4,6-dimethyl-3-cyanopyridine-2(1 H )-thione ( IIIa ) or 4,5,6-trisubstituted-3-cyanopyridine-2(1 H )-thiones ( IIIb – d ) with...
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An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
Antimicrobial resistance (AMR) has been emerging as a major global health threat and calls for the development of novel drug candidates. Metal...
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Design and synthesis of benzimidazole derivatives as apoptosis-inducing agents by targeting Bcl-2 protein
Bcl-2, an anti-apoptotic protein, is a well-known and appealing cancer therapy target. Novel series of benzimidazole derivatives were synthesized and...
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Ferrozoles: Ferrocenyl derivatives of letrozole with dual effects as potent aromatase inhibitors and cytostatic agents
In the treatment of hormone-dependent cancers, aromatase inhibitors (AI) are receiving increased attention due to some undesirable effects such as...
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Benzimidazole carbamate induces cytotoxicity in breast cancer cells via two distinct cell death mechanisms
Metastatic breast cancer (mBC) is responsible for >90% of breast cancer-related deaths. Microtubule-targeting agents (MTAs) are the front-line...
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Pharmacophore-based designing of putative ROS-1 targeting agents for NSCLC
AbstractNon-small cell lung cancer (NSCLC) is a fatal non-immunogenic malignancy, and proto-oncogene receptor tyrosine kinase (ROS-1) is one of its...
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Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine
Fenbendazole (FBZ), a benzymidazole (BZD) anthelmintic drug, is used for in-feed medication in pigs. BZD-containing drugs may induce cytochrome P450...
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Synthesis of novel carboxamide- and carbohydrazide-benzimidazoles as selective butyrylcholinesterase inhibitors
Selectively inhibiting butyrylcholinesterase (BChE) is hypothesized to help in the management of Alzheimer’s disease (AD). Several studies have...
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Live Immunostaining and Flow Cytometry of Schmidtea Mediterranea Cells
The use of flow cytometry and fluorescence-activated cell sorting to roughly separate subpopulations of cells in Schmidtea mediterranea is long...
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CDK9 inhibition as an effective therapy for small cell lung cancer
Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide...
